Objective　To understand the feedback of seven-year students of clinical medicine about the application of PBL teaching method and investigate its related factors. Methods　Four classes of seven-year students of clinical medicine of Nanjing Medical University which had received PBL teaching method were randomly selected in grade 2009 and 2010（243 students）and 233 valid questionnaires were analyzed statistically. The questionnaire has four main parts and they are about basic situation， factors that may affect the PBL Teaching， students' subjective attitude， their effect evaluation and suggestion for improvements. SPSS 11.0 was used to analyze the first part of the results with χ2 analysis（P<0.05）. Results　233valid questionnaires were recovered and 79.0%（184/233） of students held a favorable position toward PBL application in their course. It is irrelevant to no other related factors but the accessibility of information（P=0.000）. More than half of the students think it is suitable for PBL on the clinical medical students（57.5%，134/233），PBL teaching is more free and easy（51.9%，121/233）and can improve their awareness of participation（72.5%，169/233）. However more students（193） are in favor of more “traditional teaching combined with PBL， with the former domi-nated”. Conclusion　PBL teaching method in seven-year clinical medical program has been proved to be quite effective. Though with certain drawbacks， it is a good supplement to the traditional teaching methods in many aspects， and it is definitely of great significance in improving the quality of teaching.