Objective　To explore the application and effectiveness of simulated patient role play in the inquiry and the medical record writing teaching. Methods　Carrying out the teaching model of simulated patient role play in the Second Clinical Medical College of Southern Medical Uni-versity to the undergraduate students of grade 2009 snd 2010 in diagnose inquiry and medical record writing training class. A self-designed student questionnaire mainly about atmosphere of class， study enthusiasm， Self-evaluation of learning efficiency， the effect of the medical record writing in-class training and so on was used to do the survey. On the other hand， questionnaire for teachers included students' performance， students' writing ability， etc. 100 students and 50 teachers were investigated with the survey. The percentage of the options of each question on the questionnaire was calculated in order to analyze the new teaching mode. Results　The random questionnaire survey showed that 85%（85/100） of the students believe that the new teaching mode can activate classroom atmosphere and improve learning motivation. About 6２%（6２/100） of the students said medical record writing errors can be obtained and corrected timely in-class training. Most students in grade 2009 have better capacity in medical record writing than those students who did not contact with new teaching mode. Conclusion　The teaching model of “simulated patient role play” in the analogue inquiry and medical record writ-ing is efficient and feasible in medical education， which can improve students' practical ability and is expected to be applied in undergraduate medical education.