Objective　To analyze the psychological condition of postgraduates in clinical hos-pitals of colleges and universities before and after the implementation of psychological mentor scheme so as to evaluate the effect. Methods　Quantitative questionnaire （SCL-90 scale） and qualitative fo-cus interview were used to compare psychological condition of postgraduates. Totally 182 copies of questionnaires were sent to two hospitals （A and B） respectively. Then， psychological mentor scheme was carried out in A hospital. Afterwards， 206 and 140 copies of questionnaires were sent again to the hospitals respectively to compare the results. Eight student psychological consultants， 12 postgraduates and 5 postgraduate management staff were enrolled in qualitative focus interview. Excel 2003 software was adopted to establish the database and SPSS 11.0 software was used for statistical analysis. Descrip-tive analysis， frequency analysis， t test， chi-square test and variance analysis were adopted for data analysis. P<0.05 signifies for statistically significant difference. Results　Mental health status of both groups was better than the national level before the implementation （total SCL score： A hospital = 118.08±36.20； B hospital =100.33±22.90）. However， SCL-90 score of A hospital was decreased（total SCL score： 102.58±25.23） and that of B hospital （total SCL score：134.01±38.92） was in-creased （part of items higher than the adult national norm） at one year after conducting psychological mentor scheme. Conclusions　Psychological mentor scheme can effectively relieve stress and interper-sonal stress so as to reduce the general psychological problems and can help to improve mental health of the students.