Group cooperative learning is a modern education model. In order to prompt the exploration of the education model in the practice lesson of epidemiology， group cooperative learning method was adopted. There are five key steps for the conduction of group cooperative learning， includ-ing task assignment（learning points， research topics， and information retrieval） 3-5 days before the task is done， reviewing the key theoretical contents， requiring students to refer to information； orga-nizing students to review the theoretical knowledge； students' discussion and making PPT in small groups， team report by representatives， and summing up by teachers at last. Teachers should pay attention to the rationality of interior structure and group members' work. Choosing a proper research subject is very important for arousing the students' interest of study. Based on the active classroom atmosphere and students' feedback， group cooperative learning method plays an important role in pro-moting the teaching efficiency of practice lesson. However， there are still insufficiencies to be improved.