Objective　To explore the application of case based learning（CBL）combined with multimedia teaching in the clinical pediatric surgery. Methods　144 five-year program students of Pediatrics in grade 2009 were randomly and evenly divided into the experimental group using CBL with multimedia teaching， and the control group using multimedia teaching mode. After the end of the course the students of the two groups took clinical teaching knowledge test. The evaluation scores were shown by mean ± standard deviation and comparison was made between the two groups with t test. At the same time， teaching satisfaction survey was conducted among the students of the experimental group. Results　The usual results， the theoretical scores and total scores of the students in the exper-imental group were higher than those of the control group students in the operation skills， clinical thinking， and there was statistically significant difference in P<0.01.（P=0.003， P=0.002， P=0.008， P=0.009， P=0.008）. The questionnaire survey shows that compared with traditional multimedia teach-ing， CBL combined with multimedia teaching can preferably culture students' various abilities and is beneficial to learning. Conclusion　The use of CBL combined with multimedia teaching can affirma-tively improve the clinical teaching effect in the clinical pediatric surgery， and it deserves to be gen-eralized in the future teaching.