Obejective　To reform the electrocardiogram teaching mode under clinical patho phisioligy and therapy（CPPT） mode. Methods　The junior students of Grade 2010 in Second Clinical Medical College of Wuhan University were selected as subjects. The students were randomly divided into experimental group（44 students） and control group（52 students）. Control group was taught by using traditional methods for electrocardiogram（ECG） diagnostics theory， and by using Diagnostics department's own Atlas， while experimental group was taught by reformed teaching methods， and ECG reformed textbook was used in their theoretical lessons， strengthening electrocardiogram and electro physiology， cardiovascular disease combined. Meanwhile， the practice of teaching was taught by using preview speaking Figure Picture stories Case Read figure， a way to strengthen the theory practice the ory of the cycle. The questionnaire was carried out in two groups after ECG teaching. After the end of the course two groups were given packet electrocardiogram atlas test and ECG theoretical knowledge examination and the above evaluation results were statistically analyzed by using SPSS 10. Results The statistically significant differences between experimental group and the control group were in the right ventricular hypertrophy， ventricular fibrillation， WPW syndrome， et al（P<0.05）. The ratio of the ex perimental group students' liking electrocardiogram course and their recognition of electrocardiogram teaching mode was higher than that of the control group while the ratio of their thinking ECG difficult was lower than that of the control group and the difference was statistically significant difference（P<0.05）. The excellent rate and good rate of the experimental group students' theory knowledge examina tion results were higher than the control group， two groups of results distribution difference being sta tistically significant（P=0.043）. Conclusions　CPPT teaching model can effectively help students over come the difficulties in reading electrocardiogram and deepen their understanding of theoretical knowledge and memory.