Extracellular matrix （ECM） is not only one of current hot-points in medical cell biology， but also one tricky part for undergraduates to learn. This article compared chapters of ECM in medical cell biology courses and spotlighted that ECM chapter was often neglected in some domes-tic universities. Then it analyzed the possible causes， such as variable arrangement of ECM section in current textbooks. Lastly， the article recommended several suggestions， including giving a timely re-vision of the old ECM knowledge， designing an appropriate strategy for teaching， enumerating certain representative diseases to improve the ECM education. It appealed our teachers to pay more attention to how to make the module of ECM master well in near future.