The relatively independence and separation in the teaching of clinical medicine and basic medicine limits the ability training of students， and the combination of basic and clinic medicine in teaching has become the core issues and trends in medical teaching reform. So the conventional teaching patterns were reformed in pathophysiology by applying combination of basic and clinic medicine in teaching. In order to accelerate medical students to early exposure to clinical medicine Bengbu medical college changed the teachers' teaching ideas， promoted the local integration of the courses of basic and clinical medicine and the combination of basic and clinic medicine teachers in teaching， reformed mechanisms in teaching management and teaching operation. We also tested the preliminary reform effects by way of students' evaluation of the teaching and examination， and dis cussed the unfavorable factors affecting the educational reform and thought out some countermeasures.