Objective　To probe into application of clinical pathway on clinical practice teach-ing in thoracic surgery， and evaluate its effect. Methods　76 students were randomized into two groups： 35 students who accepted clinical pathway teaching were the experimental group， they were asked to carry out clinical practice in accordance with the teaching pathway； and the other 41 students were control group. The final examination included four parts： ①theoretical examination account for 20% of the total score. The test paper was randomly combined from the standardized question bank of Xinjiang Medical University， and this test included single choice questions and fill-in questions； ②clinical operational skills test account for 30% of the total score. This part included pleural puncture， dressing change， stitches remove， incision disinfection and surgical draping， and all of these opera-tions were carried out on medical patient simulators； ③clinical case analysis account for 50% of the total score. This part involved history collection， physical examination， humanistic care， case writing， diagnosis and treatment planning for new admission patients. T-test of independent samples was used to analyze all the scores of the two groups. Results　The clinical case analysis score and the total score in experimental group[（42.26±3.93） points and（81.69±6.16） points， respectively]were obviously higher than that in control group[（38.88±4.76） points and（77.39±6.83） points， respectively]； There were significant differences between the two groups（P values was 0.001 and 0.006， respectively）. Conclusion　Application of clinical pathway in clinical practice teaching may improve the effect of clinical teaching. The pathway contents and evaluation methods should be constantly improved accord-ing to teaching practice.