Objective　To evaluate the effect of modern comprehensive three-dimensional teaching method in clinical practice of respiratory medicine. Method　The problem based teaching method PBL (problem-based learning)

the standardized patient-based practice SPE/Xs (standardized patient experiences/exam) and Mini clinical examination practice Mini-CEX (Mini clinical examination exercise) method and other methods were organically combined and used in respiratory medicine clini-cal practice

and it was named “modern comprehensive three-dimensional teaching mode”. 60 students were randomly divided into the modern comprehensive three-dimensional teaching method group (30 students) and the traditional teaching method (SBL) (30 students)

using the modern com-prehensive three-dimensional teaching method and the SBL breathing internal medicine practice teaching respec-tively. After the teaching

the methods of performance testing and questionnaire survey were used to evaluate the teaching effect of two groups of students. SPSS software was used to compare t test. Results　The test results of modern three-dimensional integrated teaching method group was （86.91±4.77）， higher than that of the control group (79.00±7.51) points (t=12.4

P=0.026 0). In the subjective questions (such as discourse analysis problem and case)

modern three-dimensional integrated teaching group (47.63±2.14） points is obvi-ously superior to the traditional group (36.00±6.71) points (t=21.6

P=0.001 9). According to the results of the survey

the modern comprehensive teaching method can improve students' subjective initiative and enthusiasm for learning

improve students' ability of comprehensive analysis

promote the formation of clinical thinking

and help students master the basic knowledge and basic skills of respiratory diseases. Conclusions　In the respiratory medicine teaching

implementation of modern comprehensive three-dimensional teaching method is helpful to improving the teaching effect.