There are still some problems in the cooperation-education model of the production-learning-research

such as paying attention to the theory but ignoring the transformation of achievements

lack of original innovation in the field of biotechnology and pharmaceutical industry and so on. Besides

the advantages of school enterprise cooperation have not been effectively put into teaching. If the platform of production-learning-research constructs the case base which covers all aspects of the comprehensive knowledge of biotechnology pharmaceutics

the teachers can use the good resources from the cooperated enterprise

then can more effectively educate the students how to apply the essence of the theory of knowledge into applications. The case study teaching which is based on independent innovation will also inspire the students' innovative consciousness more effectively. National Biotechnology Engineering Research Center did teaching based on the cultivation aim of the innovative talents on the major of pharmacy. The teaching cases should be carefully selected. Various teaching methods should be flexibly applied. The information screening ability

the critical thinking ability

the concise scientific problem-solving ability

the practical ability and the cognitive occupation ability should be cultivated. The cases need to cover the vocational humanistic education and regulations. The application effects of the case teaching during 2011-2016 were evaluated.