Objective　To explore nursing experimental teaching mode on the basis of simulation technology to improve learning effect. Methods　A total of 374 nursing students of Grade 2012 to 2014 were selected as the experimental group

and 292 nursing students of Grade 2010 to 2011 were selected as the control group. The experimental group adopted the comprehensive experimental teaching based on simulation technology

while the control group used traditional teaching. At the end of the course

the experimental group students were surveyed

and the two groups of students were given a unified examination. Data analyses were performed using SPSS 17.0 and the t-test was adopted to analyze the teaching effect for comparison of the two groups. Results　The recovery rate of the questionnaires in the experimental group was 100%

and the satisfaction rate was 95%. Behavioral performance self-evaluation showed that students had high self-evaluation in improving their independent learning ability (3.47±0.63)

and low self-esteem in caring for the patient's psychological problems (2.62±0.68). The theoretical score of the experimental group was (77.03±2.55)

and the theoretical score of the control group was (71.75±3.49). The difference was statistically significant (P=0.041). Conclusion　The comprehensive nursing experiment project on the basis of simulation technology is conducive to promoting students' autonomous learning and improving their comprehensive quality and professional ability.