Objective　To explore the application of computer simulation teaching based on GasMan@ software in anesthesiology standardized nursing training. Methods　Thirty-six anesthesia nurses undergoing standardized training were selected as research objects. They were randomly divided into the traditional teaching group (group C) and the computer simulation teaching based on GasMan@ software group (group G)

with 18 nurses in each group. All the nurses received the theory test before and after the training

and the practical operation assessment and the teaching satisfaction survey were conducted after the training. SPSS 17.0 was used for independent-samples t test and chi-square test. Results　There was no significant difference in the theoretical test scores of the anesthesia nurses before class between the two groups (P > 0.05); the theoretical test

practical performance and satisfaction survey of group G were significantly better than those of group C

with statistical significance (P < 0.05). Conclusion　Computer simulation teaching based on GasMan@ software is in favor of the anesthesia nurse to learn and master the relevant theory of inhalation general anesthesia

especially to improve practical skills.