Objective　To investigate the application and effect of the virtual reality (VR) combined with the augmented reality (AR) integrated teaching system in stomatology general medical education of clinical medicine students. Methods　A total of 160 undergraduates from the five-year clinical medicine Batch 2015 of Naval Medical University were randomly divided into VR+AR group and traditional group

with 80 students in each group. A comparative analysis was made on the previous and teaching achievements of the two groups of students

and a questionnaire survey was conducted after the completion of the class. Epidata 3.0 was used to input questionnaire data

and SPSS 23.0 software was used to carry out t test

chi-square test and Fisher precision test. Results　There was no statistical difference in written test scores between the VR+AR group and the traditional group [(52.65±3.76) vs. (51.90±3.46)

P = 0.516]

but the VR+AR group was significantly higher than the traditional group in case analysis scores [(35.85±2.56) vs. (31.40±2.96)

P < 0.001] and overall performance [(88.50±4.95) vs. (83.30±4.86)

P= 0.002]. The questionnaire survey results showed that the scores of teaching mode [(92.30±6.90) vs. (85.20±7.30)

P<0.001]

teaching method [(91.70±5.90) vs. (86.00±6.70)

P=0.012] and teaching improvement [(90.70± 8.70) vs. (82.30±8.40)

P<0.001] in VR + AR group were significantly higher than those in the traditional teaching group. Conclusion　The VR combined with AR integrated teaching system can significantly improve teaching performance and teaching quality

and is convenient for teaching demonstrations and simulation operations in small oral spaces

and is especially suitable for oral general medical education for clinical medicine.