Objective　To explore the application and effect of mixed teaching based on Blackboard network teaching platform in basic chemistry teaching. Methods　The study included in 240 undergraduate students majoring in clinical medicine of Batch 2018 as the research subjects

and they were divided into the experimental group and the control group

with 120 students in each group. The control group was taught by the traditional teaching mode

and the experimental group was taught by mixed teaching method based on the Blackboard network teaching platform. A unified test was conducted for both groups of students. At the end of the course

a questionnaire survey was conducted among the students in the experimental group. SPSS 13.0 was used to process the data and independent sample t-test was performed. Results　The overall scores of the experimental group [(76.45 ± 2.62) points] were higher than those of the control group [(65.38 ± 3.09) points]

with statistical significance (t = 19.472

P < 0.001). The experimental group's satisfaction with the mixed teaching method was more than 75%. Conclusion　The mixed teaching method based on Blackboard network teaching platform is helpful to improve the quality and effect of basic chemistry teaching

and improve students' autonomous learning ability.