Objective To explore the differences in ultrasound breast imaging reporting and data system (BI-RADS) grading

virtual touch tissue imaging quantification (VTIQ) technical parameter and carbohydrate antigen 153 (CA153) in patients with breast cancer of different pathological characteristics. Methods The clinical data of 106 patients with breast cancer diagnosed by postoperative pathology in the hospital were retrospectively analyzed. Before surgery

all the patients received conventional ultrasonography for BI-RADS grading and underwent VTIQ technology to detect the maximum shear wave velocity (SWVmax) of lesions. CA153 was detected by immunosorbent assay

and the relationship between the above detection results and clinicopathological characteristics was analyzed. Results There were no statistical differences in the ultrasound BI-RADS grading distribution and CA153 level among different pathological types

histological grades

tumor sizes and pathological molecular types of breast cancer (P>0.05). The SWVmax of patients with invasive lobular carcinoma was higher than that of patients with ductal carcinoma in situ

invasive ductal carcinoma and other disease

and the SWVmax of patients with invasive ductal carcinoma and other disease was higher than that of patients with ductal carcinoma in situ (P<0.05). The SWVmax was higher in patients with histological grade 3 than grade 2 or 1

and was higher in patients with grade 2 than grade 1 (P<0.05). According to pathological molecular typing

Luminal B (HER2+) had the highest SWVmax

which was higher than that of Luminal A

Luminal B (HER2-)

Luminal B (HER2+) and triple-negative type. The SWVmax wasthe lowest in Luminal A

which was lower than other molecular types (P<0.05). The distribution of BI-RADS grades 3-4a in breast cancer patients without lymph node metastasis was more than that in patients with metastasis

and the SWVmax and CA153 were higher than those in patients with metastasis (P<0.05). Conclusion Ultrasound BI-RADS grading and CA153 level are related to the status of lymph node metastasis in patients with breast cancer

and VTIQ technical parameter SWVmax is associated with pathological type

histological grade

tumor size

pathological molecular type and lymph node metastasis

which can provide effective reference information for the clinical diagnosis and disease evaluation of breast cancer.