Abstract:Objective Two-dimensional spot tracking imaging (2D-STI) was used to evaluate the changes in right ventricular systolic function in patients with metabolic syndrome (MS) and to explore the relationship between the changes and epicardial fat thickness.Method In this study

100 participants (65 in MS patients and 35 in the control group) underwent routine echocardiography and two-dimensional spot tracking to compare the differences in clinical and ultrasonic indicators between the two groups.Pearson and Spearman correlation coefficients were used to analyze the correlation between FWS and metabolic factors.Multiple linear regression was used to analyze the independent influencing factors of FWS.Bootstrap method was used to analyze whether some clinical indicators mediated the association between EAT and FWS.Result RVGLS and RVFWS in MS group were lower than those in control group(P<0.05);FWS in case group was negatively correlated with EAT

age

systolic blood pressure

diastolic blood pressure

BMI

waist-height ratio

GLU

TG

LDL-C and TC

and positively correlated with HDL-C (P<0.05);EAT

systolic blood pressure

GLU

TG and HDL-C were independent influencing factors of FWS (P<0.05);EAT has a direct effect on FWS

and systolic blood pressure

GLU

TG

HDL-C partially mediate the effect of EAT on FWS.Conclusion Compared with conventional echocardiography

2D-STI can detect early right ventricular systolic dysfunction more sensitively and accurately in MS patients.In MS patients

EAT was an independent influencing factor of FWS;EAT partially mediates its toxic effects on the right ventricle through circulatory metabolism.