Value of contrast-enhanced ultrasound for hepatocellular carcinoma less than 3cm in patients with chronic liver disease

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Value of contrast-enhanced ultrasound for hepatocellular carcinoma less than 3cm in patients with chronic liver disease

更新时间：2024-02-04

- Value of contrast-enhanced ultrasound for hepatocellular carcinoma less than 3cm in patients with chronic liver disease
- Journal of Clinical Ultrasound in Medicine Vol. 25, Issue 12, (2023)
- 作者机构：
  
  上海交通大学医学院附属瑞金医院无锡分院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2023，
  
  Published Online：2 January 2024，
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Value of contrast-enhanced ultrasound for hepatocellular carcinoma less than 3cm in patients with chronic liver disease. [J]. Journal of Clinical Ultrasound in Medicine 25(12).(2023)
DOI：

Value of contrast-enhanced ultrasound for hepatocellular carcinoma less than 3cm in patients with chronic liver disease. [J]. Journal of Clinical Ultrasound in Medicine 25(12).(2023) DOI：

摘要

目的：研究超声造影（CEUS）对慢性肝病患者≤3cm肝细胞肝癌（HCC）的诊断价值。方法：回顾性分析我院行CEUS检查的慢性肝病患者的252个肝脏局灶性病变的影像学和临床资料，评估CEUS对≤3cmHCC的诊断价值。结果：≤3cmHCC主要表现为高-等-低增强（38.95%，37/95）、高-低-低增强（29.47%，28/95）的典型增强模式，28.42% (27/95)呈不典型增强模式。典型增强模式在＞2cm组占比高于≤2cm组，不典型增强模式在＞2cm组占比低于≤2cm组，差异有统计学意义（均P＜0.05）。典型增强模式对≤3cm HCC的诊断准确性、敏感性分别为84.52%、65.26%，AUC为0.807，结合患者为HCC高危人群且将不典型增强模式也做为≤3cmHCC的诊断标准，其准确性、敏感性分别为93.65%、93.68%，AUC 为0.937，差异有统计学意义（均P＜0.05）。结论：≤3cmHCC超声造影表现可不典型，且病灶越小不典型增强模式比例越高。结合患者为HCC高危人群，联合典型、不典型增强模式进行综合判断，可提高CEUS对≤3cmHCC的诊断效能

Abstract

Objective: To research the diagnostic value of contrast-enhanced ultrasound for hepatocellular carcinoma (diameter ≤3cm) in patients with chronic liver disease. Methods: Imaging and clinical data of 252 focal liver lesions in patients with chronic liver disease who underwent CEUS examination in our hospital were retrospectively analyzed to evaluating the diagnostic value of CEUS for HCCs ≤3cm. Results: The typical enhancement patterns of hyper – iso – hypo and hyper - hypo – hypo were revealed in 37/95(38.95%) and 28/95(29.47%)

and the atypical enhancement patterns were revealed in 27/95(28.42%) in HCCs ≤3cm . HCCs＞2cm displayed a higher proportion of typical enhancement pattern and a lower proportion of atypical enhancement pattern compared with that of HCCs ≤ 2cm (both P < 0.05). The accuracies were 84.52% and 93.65%

the sensitivities were 65.26% and 93.68%

and the AUCs were 0.807 and 0.937

respectively (all P < 0.05)

when typical CEUS enhancement pattern was considered to be diagnostic criteria for HCCs and atypical enhancement combing with the high risk of hepatocellular carcinoma was also assuming to be indicative of HCCs. Conclusions: Atypical contrast-enhanced ultrasound features may appear in HCCs ≤3cm

and the smaller the lesion

the higher the proportion. The diagnostic efficacy of CEUS for HCCs ≤3cm can be improved by combining the high-risk of hepatocellular carcinoma

typical and atypical enhancement patterns.

关键词

肝肝细胞肝癌肝脏局灶性病变超声造影

Keywords

LiverHepatocellular carcinomaFocal liver lesionContrast-enhanced ultrasound

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