Prognostic evaluation of myocardial work combined with cardiopulmonary exercise testing in patients with hypertrophic cardiomyopathy

您当前的位置：

首页 >

文章列表页 >

Prognostic evaluation of myocardial work combined with cardiopulmonary exercise testing in patients with hypertrophic cardiomyopathy

更新时间：2024-03-02

- Prognostic evaluation of myocardial work combined with cardiopulmonary exercise testing in patients with hypertrophic cardiomyopathy
- Journal of Clinical Ultrasound in Medicine Vol. 25, Issue 11, (2023)
- 作者机构：
  
  福建省龙岩市第一医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2023，
  
  Published Online：1 December 2023，
扫描看全文
Prognostic evaluation of myocardial work combined with cardiopulmonary exercise testing in patients with hypertrophic cardiomyopathy. [J]. Journal of Clinical Ultrasound in Medicine 25(11).(2023)
DOI：

Prognostic evaluation of myocardial work combined with cardiopulmonary exercise testing in patients with hypertrophic cardiomyopathy. [J]. Journal of Clinical Ultrasound in Medicine 25(11).(2023) DOI：

摘要

目的利用心肌做功联合心肺运动试验(CPET)对HCM患者的预后进行评估，并探究心肌做功参数和CPET参数与左室壁厚度的相关性。方法选取自2022年1月至2023年3月在福建省龙岩市第一医院确诊的非梗阻性HCM患者55例（男40例，女15例，平均年龄22-66岁），同时选取健康志愿者55例作为对照组。收集常规超声心动图数据并进行两组间比较。HCM患者及对照组进行心肺运动试验，比较两组心肺运动试验参数及心肌做功参数的差异，并对两组在心肺运动试验前后心肌做功的参数变化进行比较。结果 HCM组与对照组相比最大室壁厚度（MWT）、左房舒张末内径（LAD）、E/e’均明显增加，差异有统计学意义（P<0.05）。HCM 组与对照组相比心肺运动试验前左室心肌做功参数整体纵向应变（GLS）、及心肌做功指数（GWI）和有用功（GCW）均明显降低，纵向应变达峰时间离散度（PSD）明显升高，差异具有统计学意义（P<0.05），而无用功（GWW）无明显统计学意义。HCM组与对照组相比心肺运动试验参数峰值摄氧量（Peak VO2）、无氧阈（AT）、氧脉搏（VO2/HR）和代谢当量（METs）均明显降低，差异有统计学意义（P<0.05）；VE/V?CO2斜率无明显升高。HCM组心肺运动试验前后GCW无明显升高，PSD明显升高；对照组心肺运动试验前后GCW明显升高相比，PSD无明显改变。左室最大室壁厚度与PSD呈正相关（r=0.88），与GCW呈负相关（r=-0.84），与VO2呈无明显负相关性（r=-0.48）。结论心肌做功联合 CPET能够对HCM患者的预后进行有效评估，心肌有效做功参数与左室壁厚度呈负相关， CPET参数与左室壁厚度无明显相关性

Abstract

Objective To evaluate the prognosis of patients with HCM by myocardial work combined with cardiopulmonary exercise test (CPET)

and to explore the correlation between myocardial work parameters

CPET parameters and left ventricular wall thickness. Methods A total of 55 patients with non-obstructive HCM (40 males and 15 females

average age 22-66 years) diagnosed in the First Hospital of Longyan City of Fujian Province from January 2022 to March 2023 were selected

and 55 healthy volunteers were selected as the control group. Routine echocardiographic data were collected and compared between the two groups. HCM patients and control group underwent cardiopulmonary exercise test. The differences of cardiopulmonary exercise test parameters and myocardial work parameters were compared between the two groups

and the changes of myocardial work parameters before and after cardiopulmonary exercise test were compared between the two groups. Results The maximum ventricular wall thickness (MWT)

left atrial end-diastolic diameter (LAD) and E/e 'were significantly increased in the HCM group compared with the control group (P<0.05). Compared with the control group

the global longitudinal strain (GLS)

myocardial work index (GWI) and active work (GCW) of the HCM group before cardiopulmonary exercise test were significantly decreased

and the time dispersion of longitudinal strain to peak (PSD) was significantly increased (P<0.05). However

no significant statistical significance was found in GWW. Compared with the control group

the Peak oxygen uptake (Peak VO2)

anaerobic threshold (AT)

oxygen pulse (VO2/HR) and metabolic equivalent (METs) of the HCM group were significantly decreased (P<0.05). There was no significant increase in the slope of VE/V?CO2. There was no significant increase in GCW and PSD before and after cardiopulmonary exercise test in HCM group. In the control group

GCW increased significantly before and after cardiopulmonary exercise test

but PSD did not change significantly. The maximal left ventricular wall thickness was positively correlated with PSD（r=0.88）， negatively correlated with GCW（r=-0.84）， and not negatively correlated with VO2（r=-0.48）. Conclusions Myocardial work combined with CPET can effectively evaluate the prognosis of patients with HCM. There is a negative correlation between myocardial work parameters and left ventricular wall thickness

while there is no significant correlation between CPET parameters and left ventricular wall thickness.

关键词

心肌做功心肺运动试验肥厚型心肌病预后评估

Keywords

Myocardial workCardiopulmonary exercise testHypertrophic cardiomyopathyPrognostic assessment

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Logistic regression analysis of echocardiographic parameters in asymptomatic mutation gene carriers of familial hypertrophic cardiomyopathy

Assessment of left ventricular myocardial work in patients with hypothyroidism by ultrasonic non-invasive pressure-strain loopPENG Yi1,YIN Lixue2,ZHANG Li3,WANG Rui2,ZHU Hao2

Application of Noninvasive Left Ventricular Myocardial Work in patients with chronic aortic valve insufficiency who preserve left ventricular ejection fraction

The value of noninvasive myocardial work in the evaluation of right ventricular function in patients with pulmonary hypertension

Correlation Study of Echocardiographic Myocardial Work Analysis and Late Contrast-enhanced Cardiac MRI in the Evaluation of Scar After Myocardial Infarction

Related Author

纳丽莎

吴楠

梁青青

段奕全

崔丽萍

朱浩

王锐

张莉

Related Institution

宁夏医科大学临床医学院

宁夏医科大学总医院

四川省人民医院超声医学研究所,超声心脏电生理学与生物力学四川省重点实验室

电子科技大学附属医院&amp

⁰