SYNTHESIS OF m- AND p-DIMETHYLAMINOANILINE DIHYPRDCHLORIDE--THE HISTOCHEMICAL REAGENTS FOR THE DETECTION OF COLON METAPLASIA OF THE STOMACH

Department of Chemistry. Chen Beyi Li Jiasheng Xue Changjiang

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SYNTHESIS OF m- AND p-DIMETHYLAMINOANILINE DIHYPRDCHLORIDE--THE HISTOCHEMICAL REAGENTS FOR THE DETECTION OF COLON METAPLASIA OF THE STOMACH

更新时间：2024-01-17

- SYNTHESIS OF m- AND p-DIMETHYLAMINOANILINE DIHYPRDCHLORIDE--THE HISTOCHEMICAL REAGENTS FOR THE DETECTION OF COLON METAPLASIA OF THE STOMACH
- Journal of Chongqing Medical University Issue 3, Pages: 222-225(1985)
- 作者机构：
  
  重庆医学院化学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1985，
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[1]陈伯毅,李家声,薛长江.胃上皮细胞结肠化生组织化学染色试剂间-与对-二甲胺基苯胺的合成[J].重庆医学院学报,1985(03):222-225.

Department of Chemistry. Chen Beyi Li Jiasheng Xue Changjiang. SYNTHESIS OF m- AND p-DIMETHYLAMINOANILINE DIHYPRDCHLORIDE--THE HISTOCHEMICAL REAGENTS FOR THE DETECTION OF COLON METAPLASIA OF THE STOMACH. [J]. Journal of Chongqing Medical University (3):222-225(1985)
[1]陈伯毅,李家声,薛长江.胃上皮细胞结肠化生组织化学染色试剂间-与对-二甲胺基苯胺的合成[J].重庆医学院学报,1985(03):222-225. DOI：

Department of Chemistry. Chen Beyi Li Jiasheng Xue Changjiang. SYNTHESIS OF m- AND p-DIMETHYLAMINOANILINE DIHYPRDCHLORIDE--THE HISTOCHEMICAL REAGENTS FOR THE DETECTION OF COLON METAPLASIA OF THE STOMACH. [J]. Journal of Chongqing Medical University (3):222-225(1985) DOI：

摘要

间—二甲胺基苯胺与对—二甲胺基苯胺是高铁二胺组织化学染色法的二个主要成份

两者的用量比为6:1。本文报道了以N

N—二甲基苯胺为原料

硝化时同时得到间位与对位两种异构体

分别还原后即可得到此两个化合物

且两者的产量比恰能符合所需。本文还探讨了对位异构体的三种还原方法

求得较为简捷而经济的合成路线。合成的产品染色效果满意

已供全国胃癌协作组的廾个单位应用

Abstract

It has been suggested that the high iron-diamine method (HID)

which is a specific stain for gastric colon metaplasia

can be used as a diagnostic method in the detection of precancer of stomachDihydrochlorides of n

n-dimethyl-m-phenylenediamine and its p-isomer in the ratio 6:1 are the main staining ingredients of HID. Using n

n-dimethylaniline as starting material for their synthesis

m- and p-nitro isomer can be obtained in onenitration step

the former is the main product while the latter as by-product

and then reduced separately to the corresponding diamines. Both resultants conformed to the desired ratio so that the synthetic route was simplified and the cost for production was reduced.The synthetic products gave reliable stains for specimens of gastric colon metaplasia and have been supplied for the use of over 20 units engaged in research on gastric cancer.

关键词

组织化学试剂高铁二胺染色法对—二甲胺基苯胺间—二甲胺基苯胺

Keywords

High iron-diamine methodHistochemical reagentm-Dimethylamifloanlinep-Dimethylaminoanilino

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