This is a report of the treatment of experimentally infected murine trichinosis by albendazole (ABZ)

mebendazole (MBZ)

Oxibendazole (OBZ)

and thiabendazole (.TBZ). Each mouse was infected with 200 larvae of Trichinella spiralis. Infected mice were treated orally or subcutaneously with these drugs after infection. Each drug -was given by the dosage of 0.2484m mol/kg/d. Mice were sacrificed and examined 3 days after treatment. The adult worm reduction rates of MBZ and ABZ given orally were 79.8% and 57.6% respectively. They were significantly different from the control-mice (.p<0.01).However

those of OBZ and TBZ were 43.6% and 21.2% respectively (p> 0.05). The larva reduction rates of MBZ and ABZ given orally were 98.6% and 69.1% respectively; while those of MBZ

ABZ

OBZ

and TBZ given by subcutaneous injection were 94.6

99.89

99.82 and 10.96% respectively.These experimental results suggest that MBZ and ABZ may be used clinically in the treatment of trichinosis either orally or by subcutaneous injection; while OBZ is effective only by subcutaneous injection. TBZ is ineffective.