SYNTHESIS OF LAUROCAPRAM BY LIOUID-LIQUID PHASETRANSFER CATALYSIS

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SYNTHESIS OF LAUROCAPRAM BY LIOUID-LIQUID PHASETRANSFER CATALYSIS

更新时间：2024-01-17

- SYNTHESIS OF LAUROCAPRAM BY LIOUID-LIQUID PHASETRANSFER CATALYSIS
- Journal of Chongqing Medical University Issue 1, (1994)
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  CLC： TQ463.4
- Published：1994，
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[1]余瑜,靳红卫.液－液相转移催化合成月桂氮卓酮[J].重庆医科大学学报,1994(01):12-14.

SYNTHESIS OF LAUROCAPRAM BY LIOUID-LIQUID PHASETRANSFER CATALYSIS. [J]. Journal of Chongqing Medical University (1).(1994)
[1]余瑜,靳红卫.液－液相转移催化合成月桂氮卓酮[J].重庆医科大学学报,1994(01):12-14. DOI：

SYNTHESIS OF LAUROCAPRAM BY LIOUID-LIQUID PHASETRANSFER CATALYSIS. [J]. Journal of Chongqing Medical University (1).(1994) DOI：

摘要

作者研究了月桂氮酮的合成，确定以月桂醇为起始原料经溴代反应和Ｎ－烷基化反应，合成了月桂氮酮，总收率可达７８％。其中Ｎ－烷基化反应考虑到成本、操作方便等因素，使之能适应国内工业化生产的实际需要，选择了液－液相转移催化方法。经实验研究表明：以６５％～７０％氢氧化钠溶液为缩合剂，经ＴＢＡＢ为相转移催化剂，其收率可达９０％。

Abstract

Laurocapram was prepared by bromination and N-alkylation of liquid-liquid phasetransfercatalysis(PTC)from lauryl alcohol. The yeild was 78%.The experimentals of N-alkylation of PTCindicate that the yeild is 90% with condonsed agcnt (65%～70%NaOH solution)and catalyst(TBAB).This method is adapted to the needs of industrial production.

关键词

月桂氮酮氮酮相转移催出合成溴代反应N－烷基化反应

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