PHAKMACOKINETICS OF INTKAVENOUS ADMINlSTRATION OF CIPROFLOXACIN LACTATE

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PHAKMACOKINETICS OF INTKAVENOUS ADMINlSTRATION OF CIPROFLOXACIN LACTATE

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- PHAKMACOKINETICS OF INTKAVENOUS ADMINlSTRATION OF CIPROFLOXACIN LACTATE
- Journal of Chongqing Medical University Issue 4, (1995)
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  CLC： R969
- Published：1995，
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[1]向晓琴,王其南,钱元恕,杜维昭,何海霞,朱治本.静脉滴注乳酸环丙沙星的人体药物动力学[J].重庆医科大学学报,1995(04):254-257.

PHAKMACOKINETICS OF INTKAVENOUS ADMINlSTRATION OF CIPROFLOXACIN LACTATE. [J]. Journal of Chongqing Medical University (4).(1995)
[1]向晓琴,王其南,钱元恕,杜维昭,何海霞,朱治本.静脉滴注乳酸环丙沙星的人体药物动力学[J].重庆医科大学学报,1995(04):254-257. DOI：

PHAKMACOKINETICS OF INTKAVENOUS ADMINlSTRATION OF CIPROFLOXACIN LACTATE. [J]. Journal of Chongqing Medical University (4).(1995) DOI：

摘要

６名健康志愿者静脉滴注乳酸环丙沙星２００ｍｇ／ｈ，以反相高效液相法测定其血，尿中药物浓度，井据此计算有关药动学参数．静脉滴注结束时即刻血浓度为３．８４±０．３５μｇ／ｍｌＴ１／１β为３２８ｈ，Ｖｄ为１．５４Ｌ／ｋｇ，ＡＵＣ为１０．１２ｍｇｈ／Ｌ。静滴环丙沙星２００ｍｇ后２４ｈ内，尿中药物排出量占给药量的７８．９４％，说明该药主要由肾肚清除。

Abstract

n this study

the reverse- pliase HPLC was used to determine the serum and urine concen- tration of ciprofloxacin in 6 healthy volunteers during and after a 60-minute intravenous infu-sion of 200mg of its lactate. The compartnient model was determined by F value

r￣2 and AIC.Theserum drug concentration-time profile conformed to the two-compartment open model. Afterintravenous infusion

the peak level was 3.84 ± 0.35ug/ml.The elimination half-life

the apparentvolume of distribution and the area under the serum concentration curve were 3. 28h

1. 54L/kgand 10. 12mg.h/L

respectively. After a 60-minute intravenous infusion of 200mg ciprofloxacin lactate

the urinary recoveryrate winthin 24h was 78.94% of administered dose and this indicates that this drug is eliminatedmainly from the kidney

关键词

环丙沙星药物动力学HPLC

Keywords

CiprofloxacinPharmacokineticsHPLC

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