EXPRESSION OF LYSOZYME IN GASTRIC CARCINOMA AND ITS UITRASTRUCTURAL IMMUNOLOCALIZATION

Xu Man; et al

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EXPRESSION OF LYSOZYME IN GASTRIC CARCINOMA AND ITS UITRASTRUCTURAL IMMUNOLOCALIZATION

更新时间：2024-01-17

- EXPRESSION OF LYSOZYME IN GASTRIC CARCINOMA AND ITS UITRASTRUCTURAL IMMUNOLOCALIZATION
- Journal of Chongqing Medical University Issue 4, (1994)
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  CLC： R735.202
- Published：1994，
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[1]徐曼,苗德林.溶菌酶在胃癌中的表达及超微结构定位[J].重庆医科大学学报,1994(04):259-262+269.

Xu Man, et al. EXPRESSION OF LYSOZYME IN GASTRIC CARCINOMA AND ITS UITRASTRUCTURAL IMMUNOLOCALIZATION. [J]. Journal of Chongqing Medical University (4).(1994)
[1]徐曼,苗德林.溶菌酶在胃癌中的表达及超微结构定位[J].重庆医科大学学报,1994(04):259-262+269. DOI：

Xu Man, et al. EXPRESSION OF LYSOZYME IN GASTRIC CARCINOMA AND ITS UITRASTRUCTURAL IMMUNOLOCALIZATION. [J]. Journal of Chongqing Medical University (4).(1994) DOI：

摘要

应用免疫组织化学ＡＢＣ法观察溶菌酶（Ｌｙｓｏｚｙｍｅ，ＬＺＭ）在各型胃癌及其转移淋巴结、十二指肠溃疡切端胃粘膜的表达，结果显示该酶在粘液细胞型胃癌的阳性率最高，在转移淋巴结癌细胞中的表达有增强趋势，十二指肠溃疡切端的胃粘膜中主要存在于胃固有腺体的颈粘液细胞、胃小凹底部的柱状细胞及十二指肠腺细胞。蛋白Ａ胶体金免疫电镜证实ＬＺＭ主要贮存于胃癌细胞的分泌颗粒，其中以中等电子密度分泌颗粒较多。

Abstract

mmunohistochemical localization of lysozyme was cxamined in various types of gastric carcinoma and itsmetastatic lymphonodes as well as the resected gastric tissue with duodemal ulcers which were as control. The lysozyme revealed the most intense staining in the mucinous cell carcino-ma and a tendency to show the more intense reactions in metastatic cancer cells of local lymphonodes thanthose in original lesions. The enzyme is also displayed in neck mucinous cells of propria gland and columearepithlial cells at the bottom of the foveola which were in the resected gastric mocosa with duodenal ulcers.The majority of enzyme labelled by gold particals was aggregated in secretroy granules with moderate electrondensity.

关键词

溶菌酶（LZM）胃癌免疫组织化学免疫电镜

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