DETERMINATION AND SIGNIFICANCE OF IgG ANTIBOBY TO PPD IN CSF

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DETERMINATION AND SIGNIFICANCE OF IgG ANTIBOBY TO PPD IN CSF

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- DETERMINATION AND SIGNIFICANCE OF IgG ANTIBOBY TO PPD IN CSF
- Journal of Chongqing Medical University Issue 1, (1994)
- 作者机构：
  
  四川隆昌县人民医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R529.304
- Published：1994，
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[1]卢贤瑜,范筱玲,兰景刚,邓一平,陶昆.脑脊液中抗PPD抗体的检测及意义[J].重庆医科大学学报,1994(01):26-28+31.

DETERMINATION AND SIGNIFICANCE OF IgG ANTIBOBY TO PPD IN CSF. [J]. Journal of Chongqing Medical University (1).(1994)
[1]卢贤瑜,范筱玲,兰景刚,邓一平,陶昆.脑脊液中抗PPD抗体的检测及意义[J].重庆医科大学学报,1994(01):26-28+31. DOI：

DETERMINATION AND SIGNIFICANCE OF IgG ANTIBOBY TO PPD IN CSF. [J]. Journal of Chongqing Medical University (1).(1994) DOI：

摘要

用ＥＬＩＳＡ法分别检测了结核性脑膜炎、其他脑疾病和正常对照共７６份脑脊液（ＣＳＦ）中抗ＰＰＤ抗体ＩｇＧ。经统计学处理，选择ＯＤ值≥０．２０为阳性。结果表明结脑组脑脊液中抗ＰＰＤ抗体ＩｇＧ水平明显高于对照组（Ｐ＜０．０１）。该检测的敏感性和特异性分别为９２．１％和９４．７％。

Abstract

e determined the IgG antibody activity to purified protein derivative (PPD) in CSF frompatients with tuberculous mcningitis (TBM) or other brain diseases and normal control

76 cases oftotal

by ELISA

According to statistics we regarded OD ≥0.20 as positive. The results showed thatpatients with TBM clearly had highcr levels of antibody to PPD antigen than did appropriatecontrol groups(P<0.01). The sensitivity and specificity for the detection of antibody actlvity in CSFwas 92.1%and 94.7% rcspectively

This method is rapid and convenient

it can be used for earlydiagnosis of tuberculous meningitis.

关键词

结核性脑膜炎酶联免疫吸附试验（ELISA）结核菌纯蛋白衍化物（PPD）

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