STUDIES ON THE PROTECTIVE EFFECTS OF PAF RECEPTOR ANTAGO-NISTS ON THE RED BLOOD CELL MEMBRANE INJURY INDUCED BY ENDOTOXIN ADMINISTRATION IN WISTAR RATS

Lu Liying; et al

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STUDIES ON THE PROTECTIVE EFFECTS OF PAF RECEPTOR ANTAGO-NISTS ON THE RED BLOOD CELL MEMBRANE INJURY INDUCED BY ENDOTOXIN ADMINISTRATION IN WISTAR RATS

更新时间：2024-01-17

- STUDIES ON THE PROTECTIVE EFFECTS OF PAF RECEPTOR ANTAGO-NISTS ON THE RED BLOOD CELL MEMBRANE INJURY INDUCED BY ENDOTOXIN ADMINISTRATION IN WISTAR RATS
- Journal of Chongqing Medical University Issue 2, (1994)
- 作者机构：
  
  安徽医科大学
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：1994，
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[1]吕礼应,康格非.血小板活化因子受体拮抗剂对内毒素所致红细胞膜损伤的保护作用[J].重庆医科大学学报,1994(02):101-104.

Lu Liying, et al. STUDIES ON THE PROTECTIVE EFFECTS OF PAF RECEPTOR ANTAGO-NISTS ON THE RED BLOOD CELL MEMBRANE INJURY INDUCED BY ENDOTOXIN ADMINISTRATION IN WISTAR RATS. [J]. Journal of Chongqing Medical University (2).(1994)
[1]吕礼应,康格非.血小板活化因子受体拮抗剂对内毒素所致红细胞膜损伤的保护作用[J].重庆医科大学学报,1994(02):101-104. DOI：

Lu Liying, et al. STUDIES ON THE PROTECTIVE EFFECTS OF PAF RECEPTOR ANTAGO-NISTS ON THE RED BLOOD CELL MEMBRANE INJURY INDUCED BY ENDOTOXIN ADMINISTRATION IN WISTAR RATS. [J]. Journal of Chongqing Medical University (2).(1994) DOI：

摘要

本文研究了血小板活化因子（ＰＡＦ）受体拮抗剂ＢＮ５２０２１及ＢＮ５０７３９对内毒素所致的红细胞膜损伤的保护作用。结果表明，ＰＡＦ受体拮抗剂能显著改善内毒素所致的红细胞膜磷脂降解及溶血磷脂的聚集，明显降低红细胞膜损伤过程中脂质过氧化产物的堆积及稳定膜Ｎａ￣＋－Ｋ￣＋－ＡＴＰａｓｅ活力。提示ＰＡＦ可能是通过活化磷脂酶Ａ＿２引起红细胞膜磷脂降解及促进氧自由基的释放而发挥作用，从而在内毒素所致细胞损伤的病理生理过程中起到重要作用。

Abstract

he protective effects of platelet activating factor(PAF)receptor antagonists

BN52021 andBN50739

on the red blood cell membrane injuries induced by E. coli endotoxin administration werestudied on Wistar male rats.The results showed that BN52021 and Bn50739 significantly preventedthe membrane phospholipids strucrure from Phospholipase A2 involved degradation and theoverproduetion of lyso-PC

and significantly reduced the accumulation of ilpid peroxidation(MDA)

and stabilize the Na￣+-K￣+-DATPase activities of red blood cell membrane. These findingssuggest that PAF may act through the membrane phospholipids degradation induced byphospholipase A2 activation and the release of oxygen free radicals. Therefore

PAF may plays acritical role in the process of red blood cell membrane damage induced by endotoxin adininistration.

关键词

血小板活化因子内毒素红细胞膜磷脂脂质过氧化

Keywords

PIatlet activating factorendotoxinRed blood Cell mem-branephospholipidslipid peroxidation

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