PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION

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PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION

更新时间：2024-01-17

- PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION
- Journal of Chongqing Medical University Issue 1, (1994)
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  CLC： R979.1
- Published：1994，
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[1]刘宁虎,钮振.DAC－树脂血液灌流对阿霉素肝血管内输注所致心脏毒性的预防保护作用[J].重庆医科大学学报,1994(01):1-5+11.

PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION. [J]. Journal of Chongqing Medical University (1).(1994)
[1]刘宁虎,钮振.DAC－树脂血液灌流对阿霉素肝血管内输注所致心脏毒性的预防保护作用[J].重庆医科大学学报,1994(01):1-5+11. DOI：

PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION. [J]. Journal of Chongqing Medical University (1).(1994) DOI：

摘要

研究大鼠肝血管局部输注ＡＤＭ，与ＤＡＣ－树脂ＤＨＰ联合应用，观察对心肌组织ＭＤＡ含量及心肌超微结构的影响。结果表明，与对照组比较，能明显降低心肌ＭＤＡ含量，在联合应用后２小时和８天分别为０．４０５４±０．０４９７对０．７１２９±０．１６３１ｎｍｏｌ／ｍｇＣｐｒｏ（Ｐ＜０．００５）和０．５５０４±０．０６２８对０．７４５２±０．０６１２ｎｍｏｌ／ｍｇＣｐｒｏ（Ｐ＜０．００５）。超微结构结果显示联合应用均能明显减轻ＡＤＭ所致急性和亚急性心肌损害的程度。研究结果表明，联合应用能减轻ＡＤＭ所致自由基导致心肌脂质过氧化的程度，明显减轻心肌形态学的损害程度。

Abstract

The aim of our study was to invcstigato the protectivc influence of the DA C-Resinhemopcrfusion in combined use with the intra-portal adriamycin(ADM) infusion on the cardiactoxicity induced by the ADM. The results showed a favorable effect as revealed in diminishing theMDA content in cardiac muscle. Tho cardiac damages demonstrated by tho ultratructural changesin acute and subacute stage after the intra-portal adriamycin infusion had also been definitelyalleviated by combined use as compared with the control groups after 2 h and 8 days of AD Minfusion.It indicated that the combined administration of DAC-Resin hemoperfusion with intra-portaladriamycin infusion might diminish the action of lipoperoxidation in the cardiac muscle and cardiacmuscle damage as well.

关键词

吸附剂血液灌流阿霉素毒性作用

Keywords

AdsorbenthemoperfusionAdriamycinIntoxication

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