A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS

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A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS

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- A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS
- Journal of Chongqing Medical University Issue 4, (1995)
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  CLC： R587.1
- Published：1995，
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[1]王毅,龚联舫,舒昌达,陆杰.四氧嘧啶致糖尿病兔早期心功能研究[J].重庆医科大学学报,1995(04):268-271.

A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS. [J]. Journal of Chongqing Medical University (4).(1995)
[1]王毅,龚联舫,舒昌达,陆杰.四氧嘧啶致糖尿病兔早期心功能研究[J].重庆医科大学学报,1995(04):268-271. DOI：

A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS. [J]. Journal of Chongqing Medical University (4).(1995) DOI：

摘要

本文就四氧嘧啶诱导糖尿病兔子早期（４周）与正常兔左心功能进行比较，发现糖尿病兔左室内压最大值（ｐｅａｋ），舒张末期内压（ＥＤＰ），等容收缩压（ＩＰ）、室内压波下降段最大速率（－Ｓｍａｘ），心力环（Ａｒｅａ）均显著小于正常对照组（ＩＰ、Ｓｍａｘ、Ｐ＜０．０５，Ａｒｅａ，Ｐ＜０．００５，ｐｅａｋ，Ｐ＜０．００２，ＥＤＰ，Ｐ＜０．００１）。本文结果显示糖尿病兔早期左室舒张及收缩功能均减退，可能与糖尿病代谢异常以及由此造成的心肌病变有关。

Abstract

he early changes of cardiac function were studied in alloxan dialbetic rabbits in comparison with nomlal con-trols.After the onset of dialsetes for 4 weeks

left ventricular function indices including the peak pressure of leftventricule(Peak)

the end diastolic pressure(EDP)the isovolumic contraction pressure(IP)

the Peak negative -dp/dt max

(-Smax)and the area of lieart Working cycle(Area)were all significantly lower then those of normalcontirols(IP

-Smax

P < 0.005);Area(P< 0.05)EDP

P(<0.001)The results suggested that eraly decrease of leftventricular contraction and relaxation mdy be relaed to abnomal metabolism and diabetic cardiomyopathy.

关键词

四氧嘧啶糖尿病兔心功能

Keywords

alloxanDiabetic rabbitscardiac function

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Department of Nephrology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

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Division of Endocrinology, Department of Internal Medicine

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