olonic anastomotic leakage remains to be the serious complicatlon and also one of the causes ofdeath after colonic surgery. The present study showed that the hydrocortisone could retard the colonanastomotic healing in rats and the supplement of vitamin A could improve the colon anastomotichealing in rats and antagonize the inhibitory effect of the hydrocortisone. This study may provide theexperimental evidence for those patients who have received the steroid therapy for a long time and willundergo the colon resection and anastomosis

using vitamin A to improve the colon anastomosis healingand reduce the incidence of anastomotic leakage.