outhern blotting was used to detect rearrangemects of the bc1-2 gene by the two probes forchromosome 18-specific DNA fragments and for immunoglobulin hearychain joining regionfragment on chromesome 14 in 25 cases of B-NHL

also

immunophenotype and karyotype. In thepresent study

bc1-2 gene was rearranged in 56%(10/18)of follicular lymphomas and 15%(1 of 7)ofdiffuse lymphome of follicle cneter cell lineage

10 of 11 the rearranged bc1-2 fragment comigratedwith a rearranged immunoglobulin heary chain joining region fragment

confirming that is t(14

18)translocation. Our results show that the rearrangement of bc1-2 associated with the pathogenesis offollicular lymphoma.