Exploring the clinical value of plasma ET measurement in hypertensionand cornary artery disease

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Exploring the clinical value of plasma ET measurement in hypertensionand cornary artery disease

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- Exploring the clinical value of plasma ET measurement in hypertensionand cornary artery disease
- Journal of Chongqing Medical University Issue 2, (1997)
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  CLC： R544.1
- Published：1997，
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[1]陈世知,张万钟.高血压病、冠心病患者血浆内皮素水平及其临床意义初探[J].重庆医科大学学报,1997(02):130-132.

Exploring the clinical value of plasma ET measurement in hypertensionand cornary artery disease. [J]. Journal of Chongqing Medical University (2).(1997)
[1]陈世知,张万钟.高血压病、冠心病患者血浆内皮素水平及其临床意义初探[J].重庆医科大学学报,1997(02):130-132. DOI：

Exploring the clinical value of plasma ET measurement in hypertensionand cornary artery disease. [J]. Journal of Chongqing Medical University (2).(1997) DOI：

摘要

本文检测了原发性高血压和冠心病患者血浆内皮素水平，结果发现原发性高血压Ⅰ、Ⅱ期组和冠心病心功代偿组血浆ＥＴ值与正常对照组无著差异；高血压Ⅲ期组及冠心病心衰组血浆ＥＴ值明显高于正常对照组，１２例冠心病心衰患者治疗后血浆ＥＴ水平明显降低。提示ＥＴ参与了原发性高血压严重并发症及冠心病心衰的发生和发展。冠心病患者血浆ＥＴ浓度与心功不全程度有关；高血压病患者血浆ＥＴ浓度与血压高低无关。

Abstract

The purpose of this study is to explore the clinical value of plasma endothelin(EH)in EssentialHypertension(Eh)and coronary artery disease (CAD)Methods:the levels of plasma ETwere measured byradioimmunoassay at different stages in 42 EH and 45 CAD and 45 healthy personsResults:the results showedthat plasma ET levels in patients with EH in the 3rd stage and the patients withCAD in heart failure weresignificantly higher than those in the healthy.The concentration of plasma ET atthe 3rd EH stage and patientswith CAD in heart failure was 90.10±21.76pg/ml(P<0.01)and 85.33±16.07pg/ml(P<0.01).ET levels in patientswith EH stages Ⅰ

Ⅱ and patients with CAD in function compensation stage was 46.9±50.02pg/ml(P>0.05)and48.88±4.72pg/ml(P>0.05).It is suiggested that the elevation of ET may contribute to the pathophysiological changes in patients with EH or CAD.

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高血压病冠心病内皮素放射免疫

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