he efficacies of reeombinant interferoni（INFaa

1

）and interferon a

2

b（INF a

2

b）were oberved on vilological as- pect in serum in 55 patients with chronic hepatis B.One group of patients B.One group of patients were treated with INF3 x 10￣6u/day or every otherday for 3 months

the other group with INF 3 x 10￣6 u/ every other day for 3 months too . The sero-con- version rates of HBeAg and HBV-DNA were 44. 4% and 39.28% respectively at the end of treatment.（P

>

0.05）After 24 months

the sero-conversion rates of HB

3

Ag were 11.1%and 7.1%

for HBeAg and HBV-DNA

were 5l. 85% and 46. 43% respectively.The results suggest the same efficacies in these two groups By the way

itis also found that the efficay of clearance HBV is better in some patients withserum ALT above 100u/L.（P

<

0.01）