Effect of Vitamin a deficiency on the proliferation of erythroid progenitors 

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Effect of Vitamin a deficiency on the proliferation of erythroid progenitors 

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- Effect of Vitamin a deficiency on the proliferation of erythroid progenitors 
- Journal of Chongqing Medical University Issue 1, (1998)
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  CLC： R153.2
- Published：1998，
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[1]刘瑜,李廷玉,王亚平,姜蓉,瞿平.维生素A缺乏对红系早期祖细胞增殖影响的研究[J].重庆医科大学学报,1998(01):22-24.

Effect of Vitamin a deficiency on the proliferation of erythroid progenitors . [J]. Journal of Chongqing Medical University (1).(1998)
[1]刘瑜,李廷玉,王亚平,姜蓉,瞿平.维生素A缺乏对红系早期祖细胞增殖影响的研究[J].重庆医科大学学报,1998(01):22-24. DOI：

Effect of Vitamin a deficiency on the proliferation of erythroid progenitors . [J]. Journal of Chongqing Medical University (1).(1998) DOI：

摘要

采用造血祖细胞体外培养。造血生长因子生物活性检测等实验血液学技术，研究维生素Ａ缺乏（ＶＡＤ）对大鼠红系早期祖细胞（ＢＦＵ－Ｅ）增殖调控的影响。结果发现，与对照组比较，ＶＡＤ使ＢＦＵ－Ｅ集落增殖明显减少；用ＶＡＤ的脾及骨髓基质细胞培养上清液明显抑制ＢＦＵ－Ｅ集落增殖。结果提示，ＶＡＤ可能通过抑制造血生长因子白细胞介素３（ＩＬ－３）和粒单系集落刺激因子（ＧＭ－ＣＳＦ）等表达而影响红系造血。

Abstract

The effect of vitamin A deficiency (VAD) on the proliferation of erythroid progenitor cells and its mechanism were studied by using the culture of hematopoietic progentor cells and assaying biological activation of hematopoietic growth factor (HGF). The results indicated that the proliferation. of DFU - E in vitro was decreased 27%(P<0.05) in VAU rats as compared with the coantrol.BFU - E treated by using the spleen cell and bone marrow stromal cell conditioned media with VAD rats also decreased 19% and 30% respectively (P< 0.05) compared with the control. It suggests that erythropoiesis in VAD rats was inhibited by the stromal cell in hematopoieic inductive microenvironment and lymphocyte to produce some HGF (such as IL3

GM - CSF and so on)

关键词

维生素A缺乏大鼠红系早期祖细胞造血生长因子

Keywords

Vitamin A deficiencyratErythroid early progenitor cellHematopoietic growth

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