Clinical significance of inhibiting apoptosis of peripheral blood lympho- cytes from children with kawasaki disease

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Clinical significance of inhibiting apoptosis of peripheral blood lympho- cytes from children with kawasaki disease

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- Clinical significance of inhibiting apoptosis of peripheral blood lympho- cytes from children with kawasaki disease
- Journal of Chongqing Medical University Issue 3, (1998)
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  CLC： R597
- Published：1998，
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[1]易岂建,杨锡强,李成荣,李欣.川崎病患儿外周血淋巴细胞凋亡降低及其临床意义[J].重庆医科大学学报,1998(03):293-296.

Clinical significance of inhibiting apoptosis of peripheral blood lympho- cytes from children with kawasaki disease. [J]. Journal of Chongqing Medical University (3).(1998)
[1]易岂建,杨锡强,李成荣,李欣.川崎病患儿外周血淋巴细胞凋亡降低及其临床意义[J].重庆医科大学学报,1998(03):293-296. DOI：

Clinical significance of inhibiting apoptosis of peripheral blood lympho- cytes from children with kawasaki disease. [J]. Journal of Chongqing Medical University (3).(1998) DOI：

摘要

为进一步探讨川崎病（ＫＤ）的免疫发病机理，我们以正常健康儿童为对照，观察经ａｎｔｉ－ＣＤ３ｍＡｂ刺激不同培养时间的急性期ＫＤ患儿外周血淋巴细胞形态学改变和ＤＮＡ片段分析。结果显示，正常儿童外周血淋巴细胞培养的小时即可出现特征性ＤＮＡ片段改变，细胞发生胞浆浓缩，秆状或新月形核浓缩变化：ＫＤ病人需７２小时才出现相应改变。其外周血淋巴细胞培养２４，４８小时凋亡阳性细胞百分率较正常对照组低（Ｐ＜０．００１）。结果提示急性期ＫＤ病人外周血淋巴细胞凋亡产生延迟。并可能参与ＫＤ的发病。

Abstract

关键词

川崎病细胞凋亡淋巴细胞

Keywords

川崎病细胞凋亡淋巴细胞

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