Experimental study on antihemorrhagic shock effect of fructse 1,6-diphosphate

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Experimental study on antihemorrhagic shock effect of fructse 1,6-diphosphate

更新时间：2024-01-17

- Experimental study on antihemorrhagic shock effect of fructse 1,6-diphosphate
- Journal of Chongqing Medical University Issue 1, (1997)
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  CLC： R973
- Published：1997，
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[1]周远大,雷自强,何海霞,朱治本,王丕龙.1,6-二磷酸果糖抗失血性休克实验研究[J].重庆医科大学学报,1997(01):42-44.

Experimental study on antihemorrhagic shock effect of fructse 1,6-diphosphate. [J]. Journal of Chongqing Medical University (1).(1997)
[1]周远大,雷自强,何海霞,朱治本,王丕龙.1,6-二磷酸果糖抗失血性休克实验研究[J].重庆医科大学学报,1997(01):42-44. DOI：

Experimental study on antihemorrhagic shock effect of fructse 1,6-diphosphate. [J]. Journal of Chongqing Medical University (1).(1997) DOI：

摘要

本实验观察了ＦＤＰ抗失血性休克作用。３组失血性休克大鼠分别接受５％ＦＤＰ溶液（Ａ组）、５％葡萄糖溶液（Ｂ组）和生理盐水（Ｃ组）静注。给药６０ｍｉｎ后，Ａ组ＭＡＰ为１０．４±２．１ｋＰａ，与Ｂ、Ｃ组７．９±２．４和７．７±２．６ｋＰａ间均有差异（Ｐ＜０．０１）；Ａ组动物存活率７５％，而Ｂ、Ｃ组分别为２５％和１５％（Ｐ＜０．０１）；Ａ组动脉血ｐＨ和ＰａＯ２分别为７．２４±０．１４和１３．４６±１．２２ｋＰａ，与Ｂ、Ｃ组７．１４±０．１４和１０．２９±３．８４ｋＰａ与７．０２±０．１０和７．２５±２．１２ｋＰａ间有显著差异（Ｐ＜０．０１）；Ａ组回输血液再灌流后血浆ＳＯＤ和ＭＤＡ分别为１２００±１２６Ｕｍｌ－１和０．４７±０．２５ｎｍｏｌｍｌ－１，同Ｂ、Ｃ组１０８１±１１９Ｕｍｌ－１和０．９１±０．２９ｎｍｏｌ－１与８３５±９Ｕｍｌ－１和１．１３±０．１６ｎｍｏｌ－１间均有显著差异（Ｐ＜０．０１）。结果表明ＦＤＰ保护组织损伤而产生抗休克作用。

Abstract

The antihemorrhagic shock action and mechanism of fructose 1

6-diphosphate(FDP) were studied on rats. Sixty rats in hemorrhagic shock were randomly divided into three groups( n =20). Treatment group (A) received FDP (250mg/kg) as aqueous solution

and a control group (B) received 5% glucose solution (250mg/kg)

another control group (C) received equal volume of saline in the same manner. 60min after administion

the mean arterial pressure (MAP) of the group a was 10 4±2 1kPa

while those of two control (B、C) were 7 9±2 4 and 7 7±2 6kPa respectively ( P <0 01). Survival rats of groups A

B and C were 75%

25% and 15% respectively ( P <0 01). pH and PaO 2 were reduced from 7 04±0 14 and 13 46±1 22 kPa in group A to 7 14±0 14 and 10 29±3 84 kPa or 7 02±0 10 and 7 25±2 12 kPa in control group B and C ( P <0 01). 30min after retransfusion of the shed blood

serum concentration of SOD and MDA of group A were 1200±126u/ml and 0 47±0 25 nmol/ml

1081±119 u/ml and 0 91+0 29nmol/ml of 835±91μ/ml and 1 13±0 16nmol/ml in control group B and C (all P <0 01) respectively. The results showed that FDP could offectively prevent hemorrhagic shock in blood shed rats.

关键词

1，6－二磷酸果糖失血性休克缺血再灌流

Keywords

Fructose 16-diphosphateHemorrhagic shockIachemiaReperfusion

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Department of Anesthesiology,the Second Affiliated Hospital,Chongqing Medical University

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