Effect of GIK solution on hormones,carbohydrate metabolism andinsulin resistance during cardiopulmonary bypass

Fang Xiusheng; et al

您当前的位置：

首页 >

文章列表页 >

Effect of GIK solution on hormones,carbohydrate metabolism andinsulin resistance during cardiopulmonary bypass

更新时间：2024-01-17

- Effect of GIK solution on hormones,carbohydrate metabolism andinsulin resistance during cardiopulmonary bypass
- Journal of Chongqing Medical University Issue 2, (1999)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1999，
扫描看全文
[1]房秀生,黑飞龙.GIK液对体外循环内分泌、代谢紊乱及胰岛素抵抗的防治作用[J].重庆医科大学学报,1999(02):169-171.

Fang Xiusheng, et al. Effect of GIK solution on hormones,carbohydrate metabolism andinsulin resistance during cardiopulmonary bypass. [J]. Journal of Chongqing Medical University (2).(1999)
[1]房秀生,黑飞龙.GIK液对体外循环内分泌、代谢紊乱及胰岛素抵抗的防治作用[J].重庆医科大学学报,1999(02):169-171. DOI：

Fang Xiusheng, et al. Effect of GIK solution on hormones,carbohydrate metabolism andinsulin resistance during cardiopulmonary bypass. [J]. Journal of Chongqing Medical University (2).(1999) DOI：

摘要

本研究旨在探讨ＧＩＫ液对ＣＰＢ期ＩＲ、内分泌和代谢紊乱的防治作用。２０例瓣膜置换术病人分为ＧＩＫ组（ｎ＝１０）和对照组（ｎ＝１０）。分别在麻醉前、ＣＰＢ前、ＣＰＢ１５ｍｉｎ、开放主动脉５ｍｉｎ和停ＣＰＢ２０ｍｉｎ时采血测定血糖、胰岛素、Ｃ肽、生长激素、皮质醇和Ｈｃｔ。结果显示ＣＰＢ期ＧＺＫ组血糖、皮质醇浓度显著低于对照组（Ｐ＜０．０５），而胰岛素、Ｃ肽浓度显著高于对照组（Ｐ＜０．０１）。ＧＩＫ组生长激素浓度较对照组也有降低。结论：ＧＩＫ组对体外循环期导致的内分泌和代谢变化有较好的防治作用，增加胰岛素敏感性，并使胰岛β细胞分泌功能得到改善。

Abstract

o determine the improving effect of GIK Solution on insulin resistance and metabolic disorder in patients receiving valve replacement operations without diabetes during the period of CPB

20 patients were divided into 2 groups. GIK group(n=10) and control group(n=10). insulin

which was contained in GIK(I/G = 1:1)solution was infused continuously at a rate of 1u/kg/h into the patients of GIK group and nothing was done to the patients of control group during the period from induction of anesthesia to clamping aortic flow. 20 blood samples were obtained respectively from patients of two groups at the following intervals:(1) Before anesthesia (2) Before CPB (3)After 15 min CPB (4) 6 min after declamping of aorta (5) 20 min after CPB.Insulin

c - peptide

cortisol

growth hormone as well as blood glucose in samples were measured. The levels of blood glucose. cortisol are significantly reduced and c - peptide

while insulin sensitivity are increased in GIK group. Hormonal. carbohydrate metabolism responses and the secretion of pancreatic beta cells are improved by GIK Solution

关键词

体外循环胰岛素抵抗内分泌

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

CLINICAL APPLICATION OF EXTRACARDIAL PACEMAKER IN FOLLOWING OPEN-HEART SURGERY A REPORT OF 53 CASES

Euglycemic - hyperinsulinemia clamp technique in the wistar rats

The insulin resistance after traumatic brain injury in rats

Study on the effect of adiponectin on enzymatic activity of glucokinase and phosphoenolpyruvate carboxykinase in cultured rat’s liver cells

Related Author

李朝先

李晨钟

张素华

舒昌达

任伟

HE Zhaohui

et al

唐文渊

Related Institution

重庆医学院第一医院胸外科

Department of Neurosurgery,College of Clinical Medicine,Chongqing Medical University

重庆医科大学临床学院神经外科

Department of Gerontology,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院老年病科内分泌组

⁰