A prelminary observation of nitric oxide and forced expiratory volume on one second in patitnts with bronchal asthma

Zhang Guirong; et al

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A prelminary observation of nitric oxide and forced expiratory volume on one second in patitnts with bronchal asthma

更新时间：2024-01-17

- A prelminary observation of nitric oxide and forced expiratory volume on one second in patitnts with bronchal asthma
- Journal of Chongqing Medical University Issue 2, (1999)
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- Published：1999，
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[1]张桂蓉,张和生.支气管哮喘患者血浆中NO与第一秒用力呼气量的初步观察[J].重庆医科大学学报,1999(02):190-191.

Zhang Guirong, et al. A prelminary observation of nitric oxide and forced expiratory volume on one second in patitnts with bronchal asthma. [J]. Journal of Chongqing Medical University (2).(1999)
[1]张桂蓉,张和生.支气管哮喘患者血浆中NO与第一秒用力呼气量的初步观察[J].重庆医科大学学报,1999(02):190-191. DOI：

Zhang Guirong, et al. A prelminary observation of nitric oxide and forced expiratory volume on one second in patitnts with bronchal asthma. [J]. Journal of Chongqing Medical University (2).(1999) DOI：

摘要

探讨支气管哮喘患者血浆中一氧化氮的浓度以及一氧化氮与第一秒用力呼气量之间的关系，旨在探讨一氧化氮在支气管哮喘发病中的作用。测定３６例支气管哮喘病人血浆中一氧化氮的浓度，采用直线相关分析分析支气管哮喘患者经糖皮质激素治疗前、后的一氧化氮和第一秒用力呼气量的关系。结果显示支气管哮喘病人血浆中一氧化氮明显升高，与正常组比较，差异具有显著性（Ｐ＜０．００１）；哮喘病人治疗前后的第一秒用力呼气量均与相应的一氧化氮呈明显负相关。说明哮喘患者血浆中一氧化氮水平可作为判断病情与疗效的参考指标，糖皮质激素治疗哮喘的机制可能与其选择性抑制ｉＮＯＳ的活性有关。

Abstract

his study is to investigate the change of nitric oxide (NO) in serum and the possible relationship between serum nitric oxide concentrations and FEV1 in patients with bronchial asthma; in order to explore the pathogenic role the NO play in the development of bronchial asthma. Twenty health volunteers were investigated for NO (control group). Thirty - six patient. with bronchial asthma were investigated for NO and FEV1 (asthma group). Blood samples were taken before and after steroid treatment. The results before and after steroid treatment. The results suggested:①serum NO concentrations in the pwtients with bronchial asthna increaaed as umpared with the control group(P< 0.00l). ②In asthma group

the parameters after treatment were obviously different from those before treatment(P<0.06). In linear correlation analysis

FEV1 were negatively correlated with serum NO concentrations (r = - 0.71

P< 0.001 and r = - 0. 74

P< 0.001). The determination of serum NO concentrations in patients with bronchial asthma can provide a method to assess therapeutic effects. The mechanism in which steroid Was used to cure asthma may involve in selectively inhibiting the activity of NO.

关键词

哮喘一氧化氮用力呼气量

Keywords

asthmanitric oxideForced expiratory volume in one second

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Related Institution

Department of Respiratory Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Pediatrics，The Affiliated Hospital of Nanjing University of Chinese Medicine，The First Clinical Medical College of Nanjing University of Chinese Medicine

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Anesthesiology,the Children’s Hospital,Chongqing Medical University

Department of Anesthesiology,The First Affiliated Hospital of Chongqing Medical University

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