Experimental study on the effect of traditional chinese mediicinebreastcare tablet on serum concentrations of estradiol. progesterone andprolactin in rats

Liu Shengchun; et al

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Experimental study on the effect of traditional chinese mediicinebreastcare tablet on serum concentrations of estradiol. progesterone andprolactin in rats

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- Experimental study on the effect of traditional chinese mediicinebreastcare tablet on serum concentrations of estradiol. progesterone andprolactin in rats
- Journal of Chongqing Medical University Issue 1, (1999)
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  CLC： R965
- Published：1999，
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[1]刘胜春,吴凯南,厉红元,甘长清,张军,张振寰.乳康片对雌二醇、孕酮和泌乳素影响的实验研究[J].重庆医科大学学报,1999(01):28-30.

Liu Shengchun, et al. Experimental study on the effect of traditional chinese mediicinebreastcare tablet on serum concentrations of estradiol. progesterone andprolactin in rats. [J]. Journal of Chongqing Medical University (1).(1999)
[1]刘胜春,吴凯南,厉红元,甘长清,张军,张振寰.乳康片对雌二醇、孕酮和泌乳素影响的实验研究[J].重庆医科大学学报,1999(01):28-30. DOI：

Liu Shengchun, et al. Experimental study on the effect of traditional chinese mediicinebreastcare tablet on serum concentrations of estradiol. progesterone andprolactin in rats. [J]. Journal of Chongqing Medical University (1).(1999) DOI：

摘要

为探讨中成药乳康片对大鼠血浆雌二醇、孕酮和泌乳素含量的影响，采用外源性性激素复制乳腺增生动物模型，分别设置空白对照、药物对照、５倍、１０倍、２０倍治疗剂量乳康片组和ＴＡＭ组。实验３０天后果外周血放免法检测Ｅ２、Ｐ和ＰＲＬ。结果显示：１０倍乳康片组血浆Ｅ２值低于药物对照组和ＴＡＭ组（Ｐ＜０．０１，Ｐ＜０．０１）。１０倍和２０倍乳康片组Ｅ＿２值明显低于５倍组（Ｐ＜０．０１，Ｐ＜０．０１）．前两组间无显著差异。结果还显示乳康片存在对孕酮的影响。结论：乳康片有降低血浆Ｅ＿２的作用，且在作用过程中存在饱和现象。同时对孕酮有降低作用。１０倍乳康片为本实验最佳剂量。

Abstract

To evaluate the effect of traditional Chinese medicine

Breastcare Tablet

on serum levels of Estradiol (E2)

Progesterone (P) and Prolactin (PRLI in rats. Methods. Four groups of rats

which suffered fibrocystic breastdisease by sex hormone

were treated with five

ten

twenty fold treated dosages of Breastcare Tablet andTamoxifen (TAM) respectively

at the same time and two control groups were designed. Serum Ez

P and PRLwere determined by immunradiological assay after thirty days. Results.The Level of E2 of ten-fold BreastcaeTablet group was significantly lower than that of drug control group and TAM group(P<0.01

P<0.01j. The E

offive-fold Breastcare Tablet group was significantly higher than that of ten and twenty fold group. Also

Breastcare Tablet and TAM could lower progesterone. Couclusion: Breastcare Tablet can lower E

level by amechanism different from that of TAM and there existed a saturated phenomenon in the course of treatment andprogesterone will be affected by this drug as well.

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乳康片大鼠雌二醇孕酮泌乳素

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