The imbalance of cytokines and its relationship to development of Grave’s disease(GD) were investigated in 42 children with GD. The results showed:(1)The levels of IFN - γ and the ratios of IFN -γ/IL - 4 were significantly increased. but IL- 4 was significantly decreased in first visit groups compared with normal controls(P<0.001 or 0.002);Comparing antibody - positive with negative group

the levels of IFN -γ

and the ratios of IFN - γIL - 4 were significantly decreased(P< 0.05). IL - 4 was significantly increased(P< 0.001);The IFN -γ ratios of IFN -γ/IL - 4 were positively correlated with individual serum T3 and T4 levels(r= 0.54

0.56 and 0.55、0.63 respectively

P<0.05).(2) As far as further consultion children are concerned

in good theraputic effect groups

the levels of IFN-γ

and the ratios of IFN-γ/IL- 4 were markedly lower(P<0.05) .but IL -4 was unchanged(P>0.05);But in poor therapeutic effect groups . the levels of cytokines was unchanged(P>0.05). The present study demonstrates that the levels of cytokines were dislocated

which showed that Thl type was dominant and could play a major role in the development of Grave ’ s disease. But

the cytokine type of antibody - positive children began shifting to Th2 type. The detection of cytokine levels would be used for evaluating state

and diagnosing prognosis of illness.