Study of transplanted breast squamous cell carcinoma model and itsbiological features in rabbit

Wu Chuanxin; et al

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Study of transplanted breast squamous cell carcinoma model and itsbiological features in rabbit

更新时间：2024-01-17

- Study of transplanted breast squamous cell carcinoma model and itsbiological features in rabbit
- Journal of Chongqing Medical University Issue 2, (1999)
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[1]吴传新,刘长安,乔天愚,伍烽,白晋,王智彪.兔乳腺移植性鳞癌模型的建立及其生物学特征的观察[J].重庆医科大学学报,1999(02):137-140.

Wu Chuanxin, et al. Study of transplanted breast squamous cell carcinoma model and itsbiological features in rabbit. [J]. Journal of Chongqing Medical University (2).(1999)
[1]吴传新,刘长安,乔天愚,伍烽,白晋,王智彪.兔乳腺移植性鳞癌模型的建立及其生物学特征的观察[J].重庆医科大学学报,1999(02):137-140. DOI：

Wu Chuanxin, et al. Study of transplanted breast squamous cell carcinoma model and itsbiological features in rabbit. [J]. Journal of Chongqing Medical University (2).(1999) DOI：

摘要

为乳腺癌的实验研究建立大动物模型，采用组织块移植法，将ＶＸ２肿瘤组织块移植于兔乳腺组织内，观察其生物学特征。结果显示移植成瘤率１００％，荷瘤兔平均存活时间为５８±１２天，肿瘤移植后４周出现肺和腋窝淋巴结转移。移植后１周肿瘤直径为４．６７±０．４７ｍｍ，８周为１６．２１±３．２９ｍｍ。病理组织学检查见肿瘤生长于乳腺组织内，其细胞形态结构与荷瘤种兔的ＶＸ２肿瘤细胞一致。兔乳移植性鳞癌模型具有稳定的生物学特征，它为乳腺癌的基础和临床应用研究提供一种大动物模型。

Abstract

he objective of study is to establish suitable large animal tumor model for experimental study of breast carcinoma. The VX2 carcinoma tissue mass was transplanted in the breast tissue of female New Zealand Rabbits. The biological features of tumor then was observed. Results showed that the tumorigenic rate was 100%. Survival time of rabbits bearing carcinoma was approximately 58±12 days. Metastases to regional lymph nodes and lungs appeared in four weeks after transplantation.Tumor diameter was about 4.67±0.47mm within one week and 16.21 ±3.29mm within three weeks after transplantation. Histopathology indicated that tumor grew in breast tissue and infiltrated into the normal breast tissue. It had the similar biological features of VX2 carcinoma transplanted in other sites of rabbits. It is concluded that the transplanted breast squamous cell carcinoma in the rabbit had steady biological features. This makes it possible to set up a reliable large animal model for further basic and clinical study of breast carcinoma

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乳腺癌VX2肿瘤动物模型兔

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