Distribution of norfloxacin in body fluids of rabbits after iv adminitration

He Haixia; et al

您当前的位置：

首页 >

文章列表页 >

Distribution of norfloxacin in body fluids of rabbits after iv adminitration

更新时间：2024-01-17

- Distribution of norfloxacin in body fluids of rabbits after iv adminitration
- Journal of Chongqing Medical University Issue 2, (1999)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1999，
扫描看全文
[1]何海霞,陆杰,钱元恕,朱治本.诺氟沙星静注在家兔体液中的分布[J].重庆医科大学学报,1999(02):154-156.

He Haixia, et al. Distribution of norfloxacin in body fluids of rabbits after iv adminitration. [J]. Journal of Chongqing Medical University (2).(1999)
[1]何海霞,陆杰,钱元恕,朱治本.诺氟沙星静注在家兔体液中的分布[J].重庆医科大学学报,1999(02):154-156. DOI：

He Haixia, et al. Distribution of norfloxacin in body fluids of rabbits after iv adminitration. [J]. Journal of Chongqing Medical University (2).(1999) DOI：

摘要

健康雌性家兔６只，于静注诺氟沙里（２５ｍｇ／ｋｇ）前、后不同时间收集血、胆汁、脑脊液和尿液标本。用ＨＰＬＣ法测定标本中的药物浓度，所得实验数据用３Ｐ８７药代动力学软件包在微机上进行处理。结果显示，静注给药后，诺氟沙星在体内的药代动力学过程符合二室开放模型：血清、胆汁、尿中的诺氟沙星浓度均大于大多数革兰氏阳性菌和阴性菌的ＭＩＣ９０，脑脊液中的诺氟沙星浓度（峰值）等于或略高于引起脑部感染常见敏感菌的ＭＩＣ９０，表明诺氟沙星静注后，诺氟沙星能较快地分布到。上述体液中，并达到有效杀菌浓度。

Abstract

erum

bile

CSF and urine samples of six female rabbits were obtained at different times before and following administration of an iv dose of 25mg/kg. The concentration of norfloxacin in samples were determined by HPLC. The drug - time data were analyzed with 3p87 program. The results showed that the concentration of norfloxacin in serum

bile and urine were much higher than MIC90 for most pathogenic bacteria. The concentration of norfloxacin in CFS(peak level) was equal to or higher than MICd90 for common pathogenic bacteria. Experimental conalusion is that norfloxacin could distribute quickly to tissues fluids and reach the effective level of killing bacteria

关键词

诺氟沙星分布血清胆汁尿脑脊液药物动力学

Keywords

NorfloxacindistributionserumBileUrineCSFPharmacokinetic

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Correlation between serum sterol regulatory element binding protein-2 and acute cerebral infarction

CEREBRAL EMBOLISM: CLINICAL ANALYSIS OF 119 CASES

The changes of serum nitric oxide in children with glomerular diseases

A study on the levels of sICAM-1 and IL-12 in serum of patients with respiratory failure typeⅡ

Simultaneous determination of serum tauro-conjugated bile acids in intrahepatic cholestasis of pregnancy patients by high performance liquid chromatography-tendem mass spectrometry

Related Author

Tian Zhanglin

Xiong Mi

Dong Yuhan

Wei Youdong

Long Bo

秦怡玲

沈鼎烈

肖启凤

Related Institution

Department of Neurology，The First Affiliated Hospital of Chongqing Medical University

重庆医学院第一医院神经科

重庆医科大学第二临床学院内分泌研究室

重庆医科大学第二临床学院呼吸科

重庆医科大学公共卫生学院卫生统计教研室

⁰