To investigate the effect of benazepril on insulin sensitivity

in the insulin- resistant rat hepatocytes inducedwith high concentration of insulin and the control rat hepatocytes- the insulinstimulated glucoseincorporation rate

insulinase activity and the number of insulin receptor were determined with 3H-glucoseincorporation test and other techniques after both of them were treated with the rat serum containing the activeform of benazeprilfbenazeprilat).The results showed that the rat serum containing benazeprilat can increased theability of glucose uptake and metabolism. of the two kinds of hepatocytes

especialy the insulin-resistanthepatocytes

No obvious effect of the serum on insulin-degrading enzyme activity and the number of insulinreceptor was observed. The study suggests the active form of benazepril can improve the insulin sensitivity ofinsulin target cells and hamper the development of insulin.resistant state