The relationship between epidermal growth factor and diabetic nephro-pathy in NIDDM patients

Li Rong; et al

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The relationship between epidermal growth factor and diabetic nephro-pathy in NIDDM patients

更新时间：2024-01-17

- The relationship between epidermal growth factor and diabetic nephro-pathy in NIDDM patients
- Journal of Chongqing Medical University Issue 1, (1999)
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  CLC： R587.1
- Published：1999，
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[1]李蓉,汪恕萍,蒋涛,李萍,粟绍初.糖尿病患者EGF与糖尿病肾病关系的研究[J].重庆医科大学学报,1999(01):7-9.

Li Rong, et al. The relationship between epidermal growth factor and diabetic nephro-pathy in NIDDM patients. [J]. Journal of Chongqing Medical University (1).(1999)
[1]李蓉,汪恕萍,蒋涛,李萍,粟绍初.糖尿病患者EGF与糖尿病肾病关系的研究[J].重庆医科大学学报,1999(01):7-9. DOI：

Li Rong, et al. The relationship between epidermal growth factor and diabetic nephro-pathy in NIDDM patients. [J]. Journal of Chongqing Medical University (1).(1999) DOI：

摘要

为研究２型糖尿病患者尿ＥＧＦ水平的变化，用放免法测定了１０７例２型糖尿病患者和５１名健康自愿者尿ＥＧＦ、ＡＥＲ及β２──ＭＧ水平。结果显示１０７例患者尿ＥＧＦ较对照组显著降低，但当患者ＡＥＲ及β２－ＭＧ尚正常时，尿ＥＧＦ较对照组显著增高，ＡＥＲ、β２－ＭＧ增高时，尿ＥＧＦ则显著降低，且尿ＥＧＦ降低与β２－ＭＧ增高关系更密切。提示尿ＥＧＦ变化与ＤＮ关系密切，当２型糖尿病患者肾脏功能受损时，尿ＥＧＦ水平降低可能反映了肾脏功能障碍。

Abstract

To investigate the change of urinary epidermal growth factor(EGF)level in patients with NIDDM.Methods: The levels of EGF

AER and β2- MG were measured by radioimmunoassay(RIA?in 107 NIDDM patientsand 51 controls. Results: Urinary EGF in 107 diabetic patients was significantly decreased. As compared withthat in healthy subjects

urinary EGF was markedly higher in patients with normal AER and tz-MG

andsignificantly lower in those with increased AER and β2- MG

In patients with increased]AER and normal pt- MG

there was no significant change of urinary EGF. Conclusion: Urinary EGF closely relates to diabeticnephropathy and decreased EGF may provide an index of impaired renal function in NIDDM patients.

关键词

表皮生长因子糖尿病肾病

Keywords

Epidermal growth factordiabetic nephropathy

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Related Institution

Department of Obstetrics and Gynecology，Hebei Provincial Hospital of Traditional Chinese Medicine

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Department of Endocrinology,The First Affiliated Hospital of Chongqing Medical University

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The First Clinical Medical College of Nanchang University

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