The  determination  of  GAD-Ab  in  patients with  Graves’ disease

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The determination of GAD-Ab in patients with Graves’ disease

更新时间：2024-01-17

- The determination of GAD-Ab in patients with Graves’ disease
- Journal of Chongqing Medical University Issue 1, Pages: 99-100(2001)
- 作者机构：
  
  重庆医科大学第二临床学院内分泌科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R581.1
- Published：2001，
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[1]胡波,严钟德,沈兴平.Graves'病患者血清GAD-Ab含量的测定[J].重庆医科大学学报,2001(01):99-100.

The determination of GAD-Ab in patients with Graves’ disease. [J]. Journal of Chongqing Medical University (1):99-100(2001)
[1]胡波,严钟德,沈兴平.Graves'病患者血清GAD-Ab含量的测定[J].重庆医科大学学报,2001(01):99-100. DOI：

The determination of GAD-Ab in patients with Graves’ disease. [J]. Journal of Chongqing Medical University (1):99-100(2001) DOI：

摘要

目的：研究谷氨酸脱羧酶抗体（GAD-Ab）与Graves’病病程及浸润性突眼的关系。方法：用ELISA法测定51例Graves’病患者血清中的GAD-Ab。结果：20例阳性，阳性率39.2%，其中病程＜6月组，GAD-Ab阳性率7.7%，明显低于病程＞6月组（Ｐ＜0.01），Graves’病并浸润性突眼组，阳性率为57.7%，明显高于非浸润性突眼组（Ｐ＜0.01）。结论：GAD-Ab的测定有助于了解Graves’病病程及监测浸润性突眼。

Abstract

Objective:To investigate the relationship between serum antibodies to glutamic acid decarboxylase (GAD-Ab) and Graves’ disease. Methods: GAD-Ab were detected in 51 patients with Graves’ disease by means of enzymelinked immunosorbent assay (ELISA). Results: GAD-Ab were found in 20 out of 51 patients and the positive rate was 39.2%. The positive rate of GAD-Ab in patients with a duration of 6 months was 7.7%

which was significantly lower than that in patients with a duration of more than 6 months (Ｐ＜0.01). The positive rate of GAD-Ab in patients with infiltrative exophthalmos was 57.7%

which was significantly higher than that without infiltrative exophthalmos(Ｐ<0.01). Conclusion: The determination of GAD-Ab was significant in Graves’ disease.

关键词

Graves’病谷氨酸脱羧酶抗体

Keywords

Graves’ diseaseAntibodies to glutamio acid decarboxylase

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