Bioavailability of clarithromycin capsule in normal volunteers

Wei Qianping; et al

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Bioavailability of clarithromycin capsule in normal volunteers

更新时间：2024-01-17

- Bioavailability of clarithromycin capsule in normal volunteers
- Journal of Chongqing Medical University Issue 2, (1999)
- 作者机构：
  
  成都市第二人民医院泌尿科
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1999，
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[1]魏倩萍,周兴华,何海霞,周远大,蒋玉富,朱治本.克拉霉素胶囊人体相对生物利用度实验研究[J].重庆医科大学学报,1999(02):161-163.

Wei Qianping, et al. Bioavailability of clarithromycin capsule in normal volunteers. [J]. Journal of Chongqing Medical University (2).(1999)
[1]魏倩萍,周兴华,何海霞,周远大,蒋玉富,朱治本.克拉霉素胶囊人体相对生物利用度实验研究[J].重庆医科大学学报,1999(02):161-163. DOI：

Wei Qianping, et al. Bioavailability of clarithromycin capsule in normal volunteers. [J]. Journal of Chongqing Medical University (2).(1999) DOI：

摘要

１２名健康志愿者随机自身交叉口服单剂量５００ｍｇ国产克拉霉素胶囊或进口片剂进行生物利用度研究，用微生物杯碟法测定血清中克拉霉素浓度。结果表明克拉霉素胶囊和片剂两种制剂的体内药时数据符合二室模型，Ｃｍａｘ分别为２．４４和２．７８μｇ／ｍｌ；ｔｐ为２．２９和２．０７ｈ；为６．８１和７．３９ｈ；ＡＵＣ为２３．６８和２４．０５ｍｇ·ｈ·Ｌ－１。克拉霉素胶囊相对生物利用度为９９．８６±１９．２８％，表明国产克拉霉素胶囊与进口片剂具有生物等效性。关键词

Abstract

he bioavailability of clarithromycin capsule was studied in 12 normal male volunteers. A single oral dose of 500mg clarithromycin capsule or tablet was given according to a crossover design. Serum concentrations of clarithromycin were measured by bioassay. The concentration - time curves of both capsule and tablet fitted to a two - compartment open model. Peak serum levels of capsule and tablet reached 2.44 and 2.78μg/ml

at 2.29 and 2. 07h. respectively. The were 6.80 and 7.39h. The AUC were 23.68 and 24.05mg . h . L .

respectively. The relative bioavailability of capsule to tablet was 99.8±19.28%

and it demonstrated that both formation had bioequivalence.

关键词

克拉霉素药动学生物利用度

Keywords

Clarithromycinpharmacokineticsbioavailability

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