Objective: To investigate the role of prostate specific antigen (PSA) in the diagnosis and treatment of advanced prostate cancer. Methods: 11 cases of advanced prostate cancer were analysed

including the stage of tumor

PSA values

metastasis

diagnosis

antiandrogen treatment and the Flutamide withdrawal syndrome. Results: It was revealed that with the increase of serum PSA values

clinical stage of tumor increased

too. It showed the response of prostate cancer to therapy. Conclusion: PSA

as a tumor marker of prostate cancer

is important in advanced prostate cancer. It may guide management of prostate cancer in clinical practice.