A randomized controlled clinical trial of sulperazone as compared withcefotaxime in the treatment of bacterial infections

Cai Sufang; et al

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A randomized controlled clinical trial of sulperazone as compared withcefotaxime in the treatment of bacterial infections

更新时间：2024-01-17

- A randomized controlled clinical trial of sulperazone as compared withcefotaxime in the treatment of bacterial infections
- Journal of Chongqing Medical University Issue 2, (1999)
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- Published：1999，
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[1]蔡素芳,莫岚,王其南,郑行萍.舒巴哌酮钠与头孢噻肟钠随机对照治疗细菌性感染的临床评价[J].重庆医科大学学报,1999(02):172-175.

Cai Sufang, et al. A randomized controlled clinical trial of sulperazone as compared withcefotaxime in the treatment of bacterial infections. [J]. Journal of Chongqing Medical University (2).(1999)
[1]蔡素芳,莫岚,王其南,郑行萍.舒巴哌酮钠与头孢噻肟钠随机对照治疗细菌性感染的临床评价[J].重庆医科大学学报,1999(02):172-175. DOI：

Cai Sufang, et al. A randomized controlled clinical trial of sulperazone as compared withcefotaxime in the treatment of bacterial infections. [J]. Journal of Chongqing Medical University (2).(1999) DOI：

摘要

舒巴哌酮钠为头孢哌酮与舒巴坦以１：１配制的联合制剂。我们以头孢噻肟钠作为对照药，进行随机对照及开放临床试验，共治疗细菌性感染４３例，以评价其安全性及有效性。实验结果表明：试验药与对照药总的痊愈率、有效率及细菌清除率分别为８０％．９６％．１００％，５５．６％．８８．９％．９３．５％，两组对比无显著差异（Ｐ＞０．０５）。临床分离３５株致病菌药敏试验结果表明：１００％对试验药高度敏感，７１．４％对对照药高度敏感，有统计学显著差异（Ｐ＜０．０１）。试验药与对照药不良反应发生率分别为４％和５．６％，无统计学显著差异（Ｐ＞０．０５）。

Abstract

randomized controlled clinical trial to observe the efficacy and safety of sulperazone as compared with cefotaxime in the treatment of 43 cases of bacterial infections was conducted. The overall clinical efficacy rates of sulperazone and cefotaxime were 96% and 88. 9% respectively

the bacterial clearance rates 100% and 93.5 % respectively. The adverse drug reactions were mild with the rate of 4% and 5.6 % respectively. There were no statistical differences between the two groups in both efficacy and safety. The results of disc susceptibility test showed thatthe sensitive rate of bacteria to sulperazone was 100 %

which was significantly higher than that of cefotaxime. It is recommended that sulperazone can be used in the treatment of moderate and severe infections cases by sensitive bacteria

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舒巴哌酮钠头孢噻肟钠细菌感染临床试验

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