Relative bioavailability of Flunarizine Hydrochloride capsules

您当前的位置：

首页 >

文章列表页 >

Relative bioavailability of Flunarizine Hydrochloride capsules

更新时间：2024-01-17

- Relative bioavailability of Flunarizine Hydrochloride capsules
- Journal of Chongqing Medical University Issue 2, Pages: 142-144(2001)
- 作者机构：
  
  1. 重庆医科大学临床学院药剂科,重庆,400016
  2. 金花企业（集团）股份有限公司高新制药厂,西安,710043
  3. 重庆医科大学药学系!98级,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R969.1
- Published：2001，
扫描看全文
[1]柘学军,何海霞,杨崇华,陶玉,李召辉,邱峰.盐酸氟桂利嗪胶囊人体相对生物利用度研究[J].重庆医科大学学报,2001(02):142-144+150.

Relative bioavailability of Flunarizine Hydrochloride capsules. [J]. Journal of Chongqing Medical University (2):142-144(2001)
[1]柘学军,何海霞,杨崇华,陶玉,李召辉,邱峰.盐酸氟桂利嗪胶囊人体相对生物利用度研究[J].重庆医科大学学报,2001(02):142-144+150. DOI：

Relative bioavailability of Flunarizine Hydrochloride capsules. [J]. Journal of Chongqing Medical University (2):142-144(2001) DOI：

摘要

目的：研究盐酸氟桂利嗪胶囊在正常人体内的药代动力学与相对生物利用度。方法：采用HPLC法测定18名健康男性志愿者随机自身交叉单剂量po20mg金花盐酸氟桂利嗪胶囊和杨森盐酸氟桂利嗪胶囊后的血药浓度，计算两者的药代动力学参数及相对生物利用度

并以AUC（0～24）

Tmax

Cmax为指标

用方差分析、单双侧t检验及（1-2a）置信区间法分析金花胶囊与杨森胶囊的生物等效性。结果：金花与杨森盐酸氟桂利嗪胶囊的药-时曲线符合po吸收一房室模型。AUC（0～24）分别为（391.28±170.77） ng·h/ L与（407.18±174.25）ng·h／L；Tmax分别为（2.89±0.44）h 与（2.97±0.47）h ；Cmax分别为（62.70±21.67） ng/ml与（56.15±15.71）ng/ml；统计学检验结果表明AUC（0～24）

Tmax

Cmax均无显著性差异（Ｐ＞0.05）。结论：金花盐酸氟桂利嗪胶囊对杨森盐酸氟桂利嗪胶囊的相对生物利用度为（96.10±14.07）%，金花与杨森两种盐酸氟桂利嗪胶囊具有生物等效性。

Abstract

Objective: To study relative bioavailability of flunarizine hydrochloride capsules in normal volunteers. Methods: 20mg single oral of Jin Hua flunarizine hydrochloride capsules and Yang Sen flunarizine hydrochloride capsules were given to 18 healthy volunteers in an open randomized crossover study. Flunarizine hydrochloride concentration in plasma were determined by HPLC. The pharmacokinetic parameters as well as relative bioavailability were measured. Results: The concentration-time curves of Jin Hua flunarizine hydrochlo-ride capsules and Yang Sen flunarizine hydrochloride capsules were conformed to a one compartment open model. The AUC（0～24） was (391.28±170.77) μ g·h／L and (407.18±174.25)μ g·h／L

Tmax (2.89±0.44)h and (2.97±0.47)h

Cmax (62.70±21.67) ng/ml and (56.15±15.71)ng·ml-1respectively. There was no significant difference between the two formulations in the AUC（0～6）

tmax

Cmax. Conclusion: The relative bioavailability of Jin Hua flunarizine hydrochloride capsule was (96.10±14.07)% compared with the Yang Sen capsule. The result of the statistical analysis showed that the two formations were bioequivalent.

关键词

盐酸氟桂利嗪药代动力学相对生物利用度HPLC

Keywords

Flunarizine hydrochloridepharmacokineticsrelative bioavailabilityHPLC

references

Views

125

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Comparison of pharmacokinetics and relative bioavailability of two types of naproxen in healthy volunteers

A PHARMACOKINETIC STUDY ON MANNITOL AND GLYCERQL AFTER IV ADMINISTRATION IN RABBITS AND HUMANS

HIGH-PERFORMANCE LIQUID CHROMATOGRATHY ASSAY FOR NIFEDIPINE IN BIOLOGICAL FLUIDS AND KINETICS OF NIFEDIPINE METABOLISM BY HUMAN LIVER MICROSOMES

PHAKMACOKINETICS OF INTKAVENOUS ADMINlSTRATION OF CIPROFLOXACIN LACTATE

PHARMACOKINETICS OF ENOXACIN,CIPRO-FLOXACIN,OFLOXACIN AND PEFLOXACIN

Related Author

朱深银

邱峰

周远大

王宁

et al

HUANG Ping

何海霞

Zhu Zhiben and He Haixia

Related Institution

重庆医科大学临床学院临床药理研究室

Department of Pharmacy,College of Clinical Medicine, Chongqing Medical University

Laboratory of Clinical Pharmacology, First Hospital

重庆医科大学药理教研室重庆医科大学药理教研室中国医学科学院药物研究所

重庆医科大学药理教研室中国医学科学院药物研究所

⁰