Effects of gut peptides on the growth of rat pancreatic acinar cells

HAN Jun; et al

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Effects of gut peptides on the growth of rat pancreatic acinar cells

更新时间：2024-01-17

- Effects of gut peptides on the growth of rat pancreatic acinar cells
- Journal of Chongqing Medical University Issue 2, Pages: 129-131(2001)
- 作者机构：
  
  重庆医科大学消化疾病研究室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R33-33
- Published：2001，
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[1]韩军,赵旭东,唐承薇.胃肠多肽对大鼠胰腺腺泡细胞生长的影响[J].重庆医科大学学报,2001(02):129-131.

HAN Jun, et al. Effects of gut peptides on the growth of rat pancreatic acinar cells. [J]. Journal of Chongqing Medical University (2):129-131(2001)
[1]韩军,赵旭东,唐承薇.胃肠多肽对大鼠胰腺腺泡细胞生长的影响[J].重庆医科大学学报,2001(02):129-131. DOI：

HAN Jun, et al. Effects of gut peptides on the growth of rat pancreatic acinar cells. [J]. Journal of Chongqing Medical University (2):129-131(2001) DOI：

摘要

目的：了解胆囊收缩素（CCK）、蛙皮素（BBS）、生长抑素、肠血管活性多肽和胃泌素对大鼠胰腺腺泡细胞生长的影响。方法：采用大鼠胰腺腺泡细胞原代培养，测定细胞3H-胸腺嘧啶核苷掺入（3H-TdR）以观察细胞生长。结果：培养期间，细胞存活良好，保持腺泡形态，与对照组（251.5±69.1 cpm）比较，CCK、BBS明显增加了大鼠胰腺腺泡细胞的 3H-TdR，分别为361.0±57.6 和 605.5±214.2 cpm，Ｐ<0.05；而VIP组、SST组和胃泌素组则对大鼠胰腺腺泡细胞的 3H-TdR 无明显影响，Ｐ>0.05。结论：CCK、BBS有促进大鼠胰腺腺泡细胞生长的作用，SST、VIP、胃泌素则不影响胰腺腺泡细胞的生长。

Abstract

Objective: Cumulative data indicate that cholecystokinin(CCK) stimulates the growth of rat pancreas. However

it is unclear whether the receptors for gastrin bombesin (BBS)

somatostatin (SST)

vasoactive intestinal peptide (VIP) and secretin

which are expressed on the acinar cells of rat pancreas

also mediate DNA synthesis of acinar cells of rat pancreas. Methods: To address those questions

the effects of CCK

gastrin

BBS

SST and VIP on the acinar cell growth of rat pancreas were investigated through in vitro primary culture of rat pancreatic acinar cells. Results: The 3H-thymidine incorporation of pancreatic acinar cells in the group of CCK (361.0±57.6 cpm) or BBS (605.5±214.2 cpm) was significantly higher than that of control (251.5±69.1 cpm)

Ｐ< 0.05. No significant differences of 3H-thymidine incorporation of pancreatic acinar cells were found in the groups of SST

VIP and gastrin. Conclusion: Both CCK and BBS stimulated the growth of rat acinar cells. No trophic effects of VIP

SST and gastrin on rat pancreas were observed.

关键词

胃肠多肽胰腺腺泡原代培养大鼠

Keywords

Gut peptidePancreatic acinar cellprimary culturerat

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