Study on the changes of cytosolic free calcium concentration   in type 2 diabetes mellitus patients

TANG Xiaoqiong; et al

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Study on the changes of cytosolic free calcium concentration in type 2 diabetes mellitus patients

更新时间：2024-01-17

- Study on the changes of cytosolic free calcium concentration in type 2 diabetes mellitus patients
- Journal of Chongqing Medical University Issue 2, Pages: 133-135(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院血液内科
  2. 重庆医科大学临床学院血液内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2002，
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[1]唐晓琼,邓华聪,万青,邱鸿鑫.2型糖尿病患者细胞内钙离子浓度变化的研究[J].重庆医科大学学报,2002(02):133-135.

TANG Xiaoqiong, et al. Study on the changes of cytosolic free calcium concentration in type 2 diabetes mellitus patients. [J]. Journal of Chongqing Medical University (2):133-135(2002)
[1]唐晓琼,邓华聪,万青,邱鸿鑫.2型糖尿病患者细胞内钙离子浓度变化的研究[J].重庆医科大学学报,2002(02):133-135. DOI：

TANG Xiaoqiong, et al. Study on the changes of cytosolic free calcium concentration in type 2 diabetes mellitus patients. [J]. Journal of Chongqing Medical University (2):133-135(2002) DOI：

摘要

目的:探讨型糖尿病患者血中单个核细胞内2Ca2+浓度变化及其与胰岛素受体活性变化的关系。TPK方法:荧光分光分析法测定例型糖尿病及例正常对照单个核细胞内40220Ca2+浓度

并用酶联免疫法测定单个核细胞胰岛素受体酪氨酸激酶（）活性。TPK结果:型糖尿病患者单个核细胞内2Ca2+浓度显著高于正常对照组

胰岛素受体活性显著低于正常对照TPK组。相关分析显示型糖尿病患者单个核细胞内2Ca2+浓度与、显著正相关

与受体活性显著负相关。FBGFINSTPK结论:细胞内Ca2+浓度升高可能通过影响胰岛素受体活性参与胰岛素抵抗的发生。TPK

Abstract

Objective:To investigate the change of [Ca2+]i in type 2 diabetes mellites patients and its relationship with insulin receptor tyrosine kinase activity. Methods: The [Ca2+]i was assayed with fluorescence spectroscopic analysis and the insulin receptor tyrosine kinase activity was assayed with enzyme-linked immunosorbent assay method in circulating mononuclear cells in 40 type 2 diabetes mellites patients and 20 normal subjects. Results:The [Ca2+]i of circulating mononuclear cells in type 2 diabetes mellites patients was significantly higher than that in normal controls. The insulin receptor tyrosine kinase activity was significantly decreased in patients. The [Ca2+]i of circulating mononuclear cells in type 2 diabetes mellites patients was positively correlated with FBG

FINS

and negatively with the insulin receptor tyrosine kinase activity. Conclusion: The results suggest that elevation of [Ca2+]i may affect the insulin receptor tyrosine kinase activity and thus contributes to the insulin resistance.

关键词

细胞内钙离子浓度2型糖尿病胰岛素抵抗

Keywords

Cytosolic free calcium concentration ([Ca2+]i)type 2 diabetes mellitusinsulin resistance

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